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Aineistot 1-10 / 63
Structural studies of glutathione transferases towards the development of novel applications and drug design
(Turun yliopisto, 2022-10-21)
Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...
Enzymatic Studies on the Biosynthesis of Atypical Angucycline Antibiotic Lugdunomycin in Streptomyces
(2022-08-31)
Lugdunomycin, a novel antibacterial natural product isolated from Streptomyces sp. QL37, is a highly rearranged angucycline-derived polyketide with strikingly complex structure. Its proposed biosynthetic pathway involves ...
Suupatogeenin ulkokalvon rakenteettoman lipoproteiinin ilmentyminen ja osallistuminen DNA:n sisäänottoon
(2022-06-20)
Aggregatibacter actinomycetemcomitans on gram-negatiivinen, opportunistinen suupatogeeni, joka kasvaa hampaan pinnalla biofilminä aiheuttaen kroonista tulehdusta, parodontiittia. A. actinomycetemcomitansin patogeenisuus ...
Non-genetic rewiring of ERBB signaling in cancer drug tolerance
(2022-05-11)
ERBB receptors are transmembrane receptor tyrosine kinases (RTKs) that are activated by dimerization and intracellular tyrosine phosphorylation upon ligand binding. The ERBB family includes EGFR, ERBB2, ERBB3, and ERBB4 ...
Akkermansia muciniphilan ja Citrobacter rodentiumin vastakkaiset vaikutukset autoimmuunidiabeteksen kehittymiseen NOD-hiirellä
(2022-05-11)
Tyypin 1 diabeteksessa haiman Langerhansin saarekkeiden insuliinia tuottavat betasolut
tuhoutuvat autoimmuunireaktiossa, jolloin glukoositasapainon ylläpito estyy. Antigeeniä
esittelevät solut (APC, antigen presenting ...
Validation of potential CIP2A inhibitors based on computer modeling in triple-negative breast cancer
(2021-07-01)
Cancer is a wide range of diseases that are caused by unchecked multiplication of the cells due to underlying mutations. Rapidly dividing cells may achieve metastasis, which is the stage where cancer cells are able to ...
Ihmisen kollageenireseptorin aktivaatio : α1β1- ja α2β1-integriinien αI-domeenin aktivaatiomekanismien rakenne ja toiminta
(2022-06-30)
Integriinit α1β1 ja α2β1 ovat solukalvolla sijaitsevia kollageenireseptoreita, jotka vaikuttavat merkittävästi useisiin eri solufunktioihin, kuten verihiutaleiden kiinnittymiseen, mesenkymaalisten kantasolujen lisääntymiseen ...
Non-invasiivisen prenataaliseulonnan toiminnallisuuden kehittäminen
(2022-06-08)
Sikiön kehityksen aikana kromosomisto voi kehittyä virheellisesti, joka johtaa poikkeavaan kromosomimäärään. Poikkeavuudet aiheuttavat sikiölle ominaisuuksia, joista osa voi olla sikiölle hengenvaarallisia. Tässä työssä ...
Biosynthesis and evolution of anthracyclines
(Turun yliopisto, 2021-08-20)
Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...
Long-acting silica formulations - In vitro study of inflammatory response in the eye
(2021-10-18)
Inflammation is body’s typical response to unnatural, pathogenic events occurring inside the individual. In the eye, inflammation is a critical condition which can lead to sever problems, including permanent loss of vision. ...