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The role of the GABAA receptor δ subunit domains on agonist binding kinetics
(2019-11-27)
The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...
Towards targeting SAMHD1 to improve cytarabine therapy for hematological malignancies
(2018-09-26)
Acute myeloid leukemia (AML) is a hematological cancer where myeloid stem cells are transformed into malignant cells, filling and replacing the cells in a healthy bone marrow. Cytarabine is a nucleoside analog used in ...
In Vitro α-synuclein aggregation assay for studying induced cellular stress, drug targets and compounds
(2019-11-28)
Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
High throughput flow cytometry-based drug sensitivity testing for melflufen in multiple myeloma
(2020-09-04)
Multiple myeloma (MM) is a hematological plasma cell malignancy in the bone marrow. Lately, increased knowledge of MM pathogenesis and advances in therapy have improved the survival of MM patients. However, due to the ...
Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1
(2018-09-19)
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature and abnormally proliferating blast cells in the patient’s bone marrow and peripheral blood. Despite the mounting ...
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(2021-01-25)
After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...
In vitro co-culture models of peripheral blood derived cells and endothelial cells in angiogenesis
(2021-05-10)
Poor vascularization of tissue-engineered constructs is a common challenge in regenerative medicine and there is a need to find an optimal cell source that is proangiogenic and aids in the neovascularization process.
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The subcellular localization of myosin XVI in U2OS cells and its expression in the mouse brain
(2021-05-06)
Myosin XVI is a neuronally expressed member of the myosin superfamily. Many aspects of this myosin remain mysterious, but its ability to regulate actin branching and indications of its enhanced expression in early development ...
Late Chromatoid Body and its Role in RNA Regulation During Spermatid Elongation
(2021-05-04)
Spermatogenesis generates male gametes for reproduction. Spermiogenesis is the last part of spermatogenesis, where haploid male germ cells undergo differentiation from round spermatids to elongating spermatids and finally ...