Hae

The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...

Acute myeloid leukemia (AML) is a hematological cancer where myeloid stem cells are transformed into malignant cells, filling and replacing the cells in a healthy bone marrow. Cytarabine is a nucleoside analog used in ...

Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...

BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...

Transcriptional mechanisms underlying chronic neuropathic pain are still unclear. However, novel studies have suggested that the Hippo pathway and especially its compartments YAP and TAZ have a role in the pathology of ...

Herpes simplex virus 1 (HSV-1) is a common human pathogen that can be found in approximately half of the population. Typically, it causes relatively mild symptoms such as cold sores, though HSV-1 can also enter a latent ...

To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...

Streptococcus suis is an emerging catalase-negative zoonotic pathogen that uses the peroxide resistance protein (Dpr) as a defensive mechanism against oxidative stress. Dpr belongs to a family of proteins that form spherical ...

Retinitis pigmentosa (RP) is a major cause of hereditary blindness and visual disability. The prevalence of RP is estimated to be 1/4000, affecting approximately 2.5 million people worldwide. RP is a very slow-progressing ...

Human skeleton is undergoing a constant remodeling through coupled actions of bone resorbing osteoclasts and bone forming osteoblasts and this remodeling process requires a constant source of energy for the cells. Different ...