Selaus laitoksen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (rajattu näkyvyys) Bioteknologian laitos
Aineistot 1-20 / 124
-
3D-biotulostettavan verisuonimallin kehittäminen
(13.12.2022)3D-biotulostus tarjoaa mahdollisuuksia kehittää kudosmalleja, jotka vastaavat tarkemmin todellisia kudoksia, kuin perinteiset kaksiulotteiset soluviljelymallit. Näitä malleja voitaisiin käyttää esimerkiksi solujen ...suljettu -
3D-tulostettu näytteen esikäsittelykasetti molekyylidiagnostiseen vieritestausjärjestelmään
(23.10.2023)Nukleiinihapposekvenssien monistukseen perustuvat osoitustestit ovat infektio-diagnostiikassa hyödynnettäviä spesifisiä ja herkkiä molekyylidiagnostisia testejä. Niiden toiminnan edellytyksenä on monivaiheinen näytteen ...suljettu -
Affinity maturation of anti-gelsolin antibodies
(08.01.2024)Gelsolin amyloidosis is a hereditary protein misfolding disease caused by a point mutation. The change in amino acid composition affects the binding of Ca2+ to the plasma gelsolin leading to aberrant proteolytic cleavage, ...suljettu -
Akkermansia muciniphilan ja Citrobacter rodentiumin vastakkaiset vaikutukset autoimmuunidiabeteksen kehittymiseen NOD-hiirellä
(11.05.2022)Tyypin 1 diabeteksessa haiman Langerhansin saarekkeiden insuliinia tuottavat betasolut tuhoutuvat autoimmuunireaktiossa, jolloin glukoositasapainon ylläpito estyy. Antigeeniä esittelevät solut (APC, antigen presenting ...suljettu -
Analysis of GNAT gene expression in Arabidopsis thaliana
(01.07.2022)In Arabidopsis thaliana (Arabidopsis), chloroplast localized GCN5 related N acetyltransferases (GNATs) are active acetyltransferase enzymes catalyzing two distinct acetylation reactions, i.e., N terminal and lysine acetylation ...suljettu -
Anti-EPLIN antibody development
(15.05.2023)Head and neck cancers are the seventh most prevalent cancers worldwide with the predominant subtype head and neck squamous cell carcinomas (HNSCC) accounting for over 90 % of these cases. Late diagnosis and start of ...suljettu -
Anti-nukleoproteiinivasta-aineen affiniteetin parantaminen geenitekniikan keinoin ja koronavirusmäärityksen kehittäminen kuoppalevyformaatissa
(06.04.2022)Covid-19 diagnosoimiseksi on kehitetty antigeenitestejä. Ne ovat PCRmenetelmää nopeampia ja halvempia, mutta kärsivät usein alhaisesta herkkyydestä. Työssä tuotettiin ja paranneltiin vasta-aineita, jotta saavutettaisiin ...suljettu -
ATP:n havaitsemiseen perustuva menetelmä Turun vesijohtoverkoston mikrobiologisessa laadunvalvonnassa
(15.10.2023)Talousveden laatua ja turvallisuutta tarkkaillaan jatkuvasti Sosiaali- ja terveysministeriön sekä talousvesiasetuksen asettamien säädösten puitteissa. Tällä hetkellä veden mikrobiologista laatua seurataan perinteisillä ...suljettu -
Characterization and validation of bispecific antibody fragments against transferrin receptor and GABA-A receptor alpha 1 subunit
(09.06.2023)Schizophrenia is a mental disorder often characterized by multitude of different symptoms such as psychosis, hallucinations, and cognitive deficiency. While schizophrenia’s pathophysiology is largely unknown, a prevailing ...suljettu -
Characterization of novel isoform-specific HSP90 inhibitors
(16.05.2022)90kDa heat shock proteins (HSP90) belong to a family of molecular chaperones involved in the maintenance of dysregulated proteins. Therefore, HSP90 is a promising target in cancer drug research. Classical HSP90 inhibitors ...suljettu -
Characterization of the dynamics of novel conjugated bile acids in relation to the development of islet cell autoantibodies
(14.06.2023)Bile acids (BAs) are formed in the liver and modified by gut microbes (GMs) as secondary BAs. Alteration of secondary BAs has been found in children preceding the appearance of islet cell autoantibodies (ICAs) and type 1 ...suljettu -
Comparison of biological and biochemical neutralization tests to detect neutralizing antibodies against SARS-CoV-2
(14.11.2022)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causing agent of the coronavirus disease (COVID-19), has been the subject of worldwide attention since the emergence of this new virus in 2019. An instant ...suljettu -
Comparison of prime editing and base editing for generating the novel WRN R732P mutation in breast cancer cells
(22.04.2023)Breast cancer is the most common cancer among women in Finland and worldwide, but, fortunately, the survival rate in Finland is over 90 %. Genome instability and mutations are one reason for the formation of cancer. WRN ...suljettu -
CyanoConstruct: a Golden Gate DNA assembly platform for translationally optimized engineered metabolic pathways in Cyanobacteria.
(01.06.2023)Recruiting cyanobacteria as cell factories for bio-production provides a sustainable route for many products such as biofuels, etc. However, rational engineering of cyanobacteria is impeded by the unpredictability of ...suljettu -
Design and evaluation of the CRISPR-Cas9 genome editing approach in hippocampal neurons for defining neurodegenerative mechanisms in Parkinson's disease
(04.08.2021)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. In order to improve diagnostic and therapeutic approaches for PD, disease etiology needs to be better understood. Advances in gene editing ...suljettu -
Designing a quantitative PCR assay for fetal RhD genotyping from maternal plasma derived cell-free fetal DNA
(17.05.2022)Hemolytic disease of the fetus and newborn (HDFN) is typically caused by maternal alloimmunization against antigens of RhD positive red blood cells. During pregnancy, these anti-RhD antibodies can induce the destruction ...suljettu -
Detection of aberrant glycosylations in head and neck squamous cell carcinomas
(27.04.2021)Head and neck squamous cell carcinomas (HNSCC) are very aggressive types of cancers that cause around 300 000 deaths annually. Being the sixth most frequent type of malignancy globally, consumption of both tobacco and ...suljettu -
Detection of methionine 1-linked ubiquitin chains in intestinal inflammation and cancer models
(25.04.2023)Ubiquitination is a post-translational modification, which involves the attachment of polyubiquitin chains to substrate proteins. Methionine 1-linked ubiquitin (Met1-Ub) chains have an important role in nuclear factor-κB ...suljettu -
Development and application of anti-immune complex antibodies for the detection of aflatoxin M1
(31.01.2023)Aflatoxin M1 (AFM1) is a mycotoxin that can be found in milk or milk products derived from livestock that have eaten contaminated feed. AFM1 has toxic and carcinogenic properties to human health due to which its detection ...suljettu -
Development of a long troponin T fragment assay for myocardial infarction diagnosis
(31.10.2023)Myocardial infarction (MI) is one of the leading causes for loss of life in developed countries. MI occurs when oxygenated blood flow to the cardiac muscle declines or is totally terminated. Diagnosis of MI relies on ...suljettu