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18F-Labeled Presynaptic Dopaminergic Tracers. Synthesis, Radiochemical Analyses, and Preclinical Evaluation of [18F]FDOPA and [18F]CFT
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 999 (Turun yliopisto, 27.01.2012)Dysfunction of the dopaminergic system in brain is involved in several pathological conditions such as Parkinson’s disease and depression. 2β-Carbomethoxy-3β-(4-[18F] fluorophenyl)tropane ([18F]CFT) and 6-[18F]fluoro-L-dopa ... -
[18F]Fluoride : molar activity and utility in radiosynthesis and in biological applications
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1423 (Turun yliopisto, 18.05.2019)A radiopharmaceutical is a radioactive isotope combined with a biologically interesting molecule that targets specific tissues, organs, or cells in the living body. This special class of medicinal product has applications ... -
A cell spot microarray method for high-throughput biology
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 969 (Turun yliopisto, 22.06.2011)High-throughput screening of cellular effects of RNA interference (RNAi) libraries is now being increasingly applied to explore the role of genes in specific cell biological processes and disease states. However, the ... -
A Comparative Study of the Effectiveness of a Prefabricated Appliance and a Stabilization Appliance in the Treatment of Myofascial pain and Headache
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 964 (Turun yliopisto, 10.06.2011)The aim of this thesis was to evaluate the short- and long-term effectiveness of a prefabricated occlusal appliance (R) on patients with myofascial pain and headache by comparing it with the treatment of the stabilization ... -
A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1028 (Turun yliopisto, 14.09.2012)Cells of epithelial origin, e.g. from breast and prostate cancers, effectively differentiate into complex multicellular structures when cultured in three-dimensions (3D) instead of conventional two-dimensional (2D) adherent ... -
A Health game as an intervention to support tobacco-related health literacy among early adolescents
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1357 (Turun yliopisto, 18.05.2018)The aim of this study was to develop and evaluate the feasibility of a health game intervention supporting tobacco-related health literacy in 10 to 13-year-old early adolescents. The study had two phases. During the ... -
A Model for patient engagement integration in perinatal eHealth development and quality assurance
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1720 (Turun yliopisto, 30.06.2023)The aim of this study was to construct a model for patient engagement integration in perinatal eHealth development and quality assurance. The model was developed in four phases. The first three phases produced evidence for ... -
A New practice model to organize perioperative nursing care
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1574 (Turun yliopisto, 15.10.2021)The aim of this research was to investigate the effects of a new perioperative practice model (NPPM) on patient outcomes (anxiety, health-related quality of life, satisfaction), nursing outcomes (organizational engagement), ... -
A novel concept of non-metallic orthopedic implants for load-bearing applications
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1654 (Turun yliopisto, 23.09.2022)Metallic implants have remained the state of the art for skeletal reconstruction for over a hundred years. However, the excessive stiffness of metallic implants can lead to unphysiological direct bone healing and bone ... -
A Systems Biology Analysis of PP2A Functions in Cancer Cells
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1264 (Turun yliopisto, 20.01.2017)Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ... -
Acceptance and Use of Information Technology among Nurses in Psychiatric Hospitals
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 837 (Turun yliopisto, 27.02.2009)<b>Hoitajien informaatioteknologian hyväksyntä ja käyttö psykiatrisissa sairaaloissa</b> Informaatioteknologian (IT) käyttö ei ole ollut kovin merkittävässä roolissa psykiatrisessa hoitotyössä, vaikka IT sovellusten on ... -
Acid-base Balance and Oxidative Metabolism in Calcified Tissues
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 906 (Turun yliopisto, 11.06.2010)The calcified tissues, comprising bone and cartilage, are metabolically active tissues that bind and release calcium, bicarbonate and other substances according to systemic needs. Understanding the regulation of cellular ... -
Actin- and adhesion-mediated regulation of cell states : from cancer to stem cells
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1670 (Turun yliopisto, 28.10.2022)Actin cytoskeleton and cell adhesion regulate cell shape, contractility and motility, all of which play important roles in development of normal tissues and diseases. Integrins are adhesion receptors that are connected ... -
Acute appendicitis – a study with special reference to diagnostics, severity assessment and association with appendiceal neoplasms
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1411 (01.03.2019)Acute appendicitis is the most common indication for emergency abdominal surgery. Today, it is generally accepted that acute appendicitis does not invariably progress to perforation. Recent studies have shown that the ... -
Acute biochemical diagnostics of mild traumatic brain injury : A clinical study
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1527 (Turun yliopisto, 18.12.2020)Traumatic brain injury (TBI) is a global health burden. Most cases diagnosed with TBI are mild traumatic brain injury (mTBI), however, no unanimous definition of mTBI exists. Although most of the patients with mTBI recover ... -
Acute diverticulitis – Aspects of diagnostics with computed tomography imaging
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1827 (Turun yliopisto, 14.02.2025)The incidence of acute diverticulitis – common disease in Western countries – is increasing worldwide. Acute diverticulitis can be divided by its degree of severity into uncomplicated and complicated forms. Accurate diagnosis ... -
Acute respiratory illness and respiratory viruses: Associations to older citizens’ state of health
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1744 (Turun yliopisto, 24.11.2023)The role of many respiratory virus infections among older individuals remains unclear. Respiratory virus detection provides prognostic information about asthma development in children suffering from severe lower airway ... -
Adenosine metabolism in cancer: unveiling new therapeutic opportunities
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1855 (Turun yliopisto, 07.03.2025)Tumor immune evasion, a hallmark of cancer, allows malignant cells to escape immune surveillance and elimination. While immune checkpoint inhibitors, such as anti-PD-1, anti-CTLA-4, and anti-PD-L1 antibodies, have ... -
Adherence to Treatment in Psychotic Disorders - Development of user-centered mobile health intervention
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1227 (Turun yliopisto, 13.05.2016)The aim of this study was to explore adherence to treatment among people with psychotic disorders through the development of user-centered mobile technology (mHealth) intervention. More specifically, ... -
Adiponectin and Leptin and Their Associations with Cardiovascular Risk Factors and Markers of Subclinical Atherosclerosis in Young Adults
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1271 (Turun yliopisto, 03.03.2017)Background: Effective prevention of atherosclerosis requires identification of individuals at high risk already in childhood. Adipose tissue produces various proteins that participate in the regulation of metabolism and ...
