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Radiolabeling of spherical oligonucleotides for targeted and pretargeted PET imaging : Biological evaluation of structural effects by using a tetrazine [¹⁸F]fluoroglycoconjugate
(Turun yliopisto, 2024-09-13)
Positron emission tomography (PET) is a sensitive and non-invasive molecular imaging modality with various applications, including drug discovery and the development of novel therapeutics evaluation at an early stage. ...
Sediment movement in cold-region fluvial environments: Monitoring flow-sediment interaction from rivers to estuaries
(Turun yliopisto, 2022-06-11)
Comprehensive studies reflecting sediment flux in seasonal cold-region fluvial environments via local sediment processes are rare in the literature. To understand sediment flux, flow-sediment interaction needs to be studied ...
Highlighting the chemical diversity of plants: modern tools for chemistry education
(Turun yliopisto, 2022-10-28)
The chemical diversity of plants is enormous as plants produce a variety of compounds that play key roles, for instance, in the growth, defence and reproduction of plants. This diversity is not well recognised in chemistry ...
Towards cyclopalladated therapeutic oligonucleotides
(Turun yliopisto, 2021-11-19)
Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...
Memristor devices based on low-bandwidth manganites
(Turun yliopisto, 2022-12-12)
This dissertation investigates the phenomenon of resistive switching (RS) in lowbandwidth mixed-valence perovskite manganite oxides. In particular, the compounds Pr0.6Ca0.4MnO3 and Gd1−xCaxMnO3 with x between 0 and 1 are ...
On Problems of optimal timing under regime switching and poisson constraints
(Turun yliopisto, 2024-11-29)
The focus of this thesis is in analyzing optimal stopping (OSP) and impulse control problems (ICP) of linear diffusions under regime switching and Poisson constraints. Regime switching means that the problem’s parameters ...
Organomercury oligonucleotides as artificial ribonucleases
(Turun yliopisto, 2024-05-10)
Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...
Tuning Photochromic Sodalites across the Visible Spectrum
(Turun yliopisto, 2023-06-16)
Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...
Geochemistry of felsic, mafic and ultramafic rocks in the suprasubduction zone Mawat ophiolite, Northeast Iraq
(Turun yliopisto, 2021-11-19)
The Mawat ophiolite is a remnant from the Neotethyan oceanic lithosphere exposed within the Zagros Suture Zone, northeastern Iraq. This thesis focuses on the evolution of the mantlederived magma and their temporally and ...
Observational studies of accreting X-ray pulsars in a broad energy range
(Turun yliopisto, 2022-11-04)
Among all interesting astrophysical objects in the universe, only a few are capable of improving our understanding of physics under extreme conditions. Accreting neutronstars are one of these objects. These compact objects ...