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Aineistot 1-10 / 17
Organomercury oligonucleotides as artificial ribonucleases
(Turun yliopisto, 2024-05-10)
Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...
Tuning Photochromic Sodalites across the Visible Spectrum
(Turun yliopisto, 2023-06-16)
Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...
Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates
(Turun yliopisto, 2021-12-18)
Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ...
Monitoring cellular Guanosine triphosphate (GTP) and GTP associated proteins
(Turun yliopisto, 2024-03-01)
Guanosine-5'-triphosphate (GTP) is an essential molecule for cell survival and function. Although free GTP plays a crucial role in several cellular processes, most studies focus solely on the protein bound GTP and its ...
Versatile Ultrathin Films of Conducting Polymers by Vapor Phase Polymerization at Atmospheric Pressure: Synthesis, Process Optimization, and Characterization
(Turun yliopisto, 2022-12-09)
The limitations such as toxicity, brittleness, scarcity, and high cost of currently available materials for energy storage and transparent electrode applications in bendable electronics create a need for green, sustainable, ...
Electrocatalysts for environmental mitigation: Synthesis, characterization and application
(Turun yliopisto, 2024-05-10)
The growing environmental crisis has strengthened interest in conversion technologies within the chemical industry, particularly in the reducing of greenhouse gases and minimizing toxic chemicals. To combat these issues, ...
N-Methoxyoxazolidineligation in oligonucleotides
(Turun yliopisto, 2024-09-27)
Vedessä tapahtuvia kytkentäreaktioita hyödynnetään modernissa lääkekehityksen kemiassa ja bioteknologisissa sovelluksissa. Esimerkiksi DNA-templatoidun synteesin avulla valmistetaan laajoja molekyylikirjastoja, jotka ...
Targeted delivery of molecular spherical nucleic acids
(Turun yliopisto, 2023-09-22)
During the last decades, oligonucleotides (ONs) have emerged as an alternative therapeutic modality for a variety of diseases. They can target disease mechanisms that are considered undruggable by small molecular drugs ...
Aminophenolato complexes of Mo, W and V In catalytic alkene epoxidation and catechol oxidation
(Turun yliopisto, 2021-11-05)
Mo, W and V are found naturally in metalloenzymes such as the Mo/W oxotransferases and the V haloperoxidases (VHPOs). These enzymes catalyze oxidation reactions related to C, N, S metabolism as well as halogenation. Cu and ...
Recognition of single- and double-stranded nucleic acids by covalently mercurated oligonucleotides
(Turun yliopisto, 2021-03-02)
Metal-mediated base pairs have attracted considerable attention during the past decades for their potential in bio- and nanotechnological applications. The introduction of metal ions into DNA or RNA not only stabilizes ...