Hae
Aineistot 11-20 / 20
Regulation of B cell development by transcription factors IRF4 and BACH2
(Turun yliopisto, 2017-10-20)
B lymphocytes—major cell types mediating an adaptive immunity—recognize a vast variety of structures by B cell antigen receptors (BCR). Activated B cells can form germinal centers, undergo antigen-induced affinity maturation ...
Multi-omics analysis of early molecular mechanisms of type 1 diabetes
(Turun yliopisto, 2021-12-17)
Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ...
Integration of genome-wide datasets to understand regulation of human T-helper cell differentiation
(Turun yliopisto, 2020-06-05)
T-helper cells are an important part of the immune system and adaptive immunity. Over the course of the immune response, under the influence of various cytokines, T-helper cells differentiate into various subsets each of ...
Immunology of bladder cancer
(Turun yliopisto, 2019-09-20)
Bladder cancer (BC) is a highly prevalent disease with wide variety in outcome. Non-muscle invasive tumors have good prognosis but are prone to recur and, furthermore, have a major risk of progression. Muscle-invasive ...
Polymorphisms and genetic susceptibility of Type 1 diabetes and Addison’s disease
(Turun yliopisto, 2018-11-23)
The HLA region accounts for approximately half of the genetic susceptibility in type 1 diabetes. The strongest genetic association with type 1 diabetes (T1D) is conferred by HLA class II alleles, where particular combinations ...
Data-independent acquisition mass spectrometry for human gut microbiota metaproteome analysis
(Turun yliopisto, 2022-01-13)
Human digestive tract microbiota is a diverse community of microorganisms having complex interactions between microbes and the human host. Observing the functions carried out by microbes is essential for gaining understanding ...
Immunoregulatory roles of CD73 in lymphatic endothelial and myeloid cells
(Turun yliopisto, 2021-01-29)
The immune system is a fascinating product of the interaction and cooperation of amultitude of cells and tissues. It is thereby able to distinguish between “friend” and “foe” and protect the host from a great variety of ...
HLA-A*24 and B*39 alleles in type 1 diabetes risk
(Turun yliopisto, 2020-12-11)
Type 1 diabetes is an autoimmune disease, and it is one of the most common chronic diseases of childhood. An asymptomatic pre-diabetes period preceding the clinical onset is characterized by autoantibodies against pancreatic ...
Lymphatic endothelial cells regulate traffic in lymph nodes
(Turun yliopisto, 2020-10-23)
Afferent lymphatic vessels transport leukocytes and soluble molecules from the periphery to lymph nodes. These vessels are lined with lymphatic endothelial cells (LEC), which are also present in lymph node sinuses. Lymph ...
Role of Clever-1 in Leukocyte Trafficking and Inflammation
(Turun yliopisto, 2022-09-23)
Secondary lymphoid organs, including lymph nodes (LNs) and the spleen, play an important role in protecting us against invading pathogens. While LNs are connected to lymphatic vessels and receive antigens from the peripheral ...