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Aineistot 191-200 / 232
Novel PP2A biomarkers in cancer
(Turun yliopisto, 2021-04-09)
Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited ...
Genetics of inherited dementing disorders – Special emphasis on Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease and primary familial brain calcification
(Annales Universitatis Turkuensis D 1266Turun yliopisto, 2017-01-21)
Advances in genotyping and sequencing technologies have enabled the identification of common and rare genetic variation associated with dementia. This thesis aimed to examine the genetic background of ...
New perspectives on the melanocortins and their cardiovascular effects: Potential implications for the treatment of cardiovascular diseases with melanocortin analogues
(Annales Universitatis Turkuensis D 1050Turun yliopisto, 2013-01-11)
The melanocortin peptides, including melanocyte-stimulating hormones, α-, β- and
γ-MSH, are derived from the precursor peptide proopiomelanocortin and mediate their
biological actions via five different melanocortin ...
Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...
Identification of predictive ERBB mutations for targeted treatment
(Turun yliopisto, 2023-05-26)
Predictive biomarkers, such as genetic alterations, are used in personalized cancer medicine to target treatment. Genes encoding members of the ERBB family of receptor tyrosine kinases are well known to harbor genetic ...
Novel tools for identification of oncogenic driver mutations
(Turun yliopisto, 2023-02-09)
Genetic alterations contribute to the development and pathogenesis of several human cancers. These mutations accumulate in a cancer tissue over the course of time due to the instability of the cancer genome. Large-scale ...
Fusion genes in high-grade serous ovarian cancer
(Turun yliopisto, 2023-12-08)
High-grade serous ovarian cancer (HGSC) is the most common and lethal subtype of ovarian cancer. Debulking surgery is the primary treatment, supplemented by platinum and taxane combination chemotherapy. The response to ...
Function of Germline-specific Ribonucleoprotein granules-from germline to cancer
(Turun yliopisto, 2023-12-15)
Male germ cells undergo complex differentiation from embryonic germ cells, through postnatal spermatogenesis to highly specialized spermatozoa. Precise regulation of gene expression is critical for meiosis and morphological ...
Re-educating macrophages to activate antitumor immunity: One Clever Immunotherapy
(Turun yliopisto, 2023-04-14)
The immune system is our constant protector against external foes but also against our own incipient malignant cells. Unfortunately, developing cancers often learn to shut down the antitumor immune response or even to ...
The role of melanocortin-1 and -3 receptors in inflammation and atherosclerosis
(Turun yliopisto, 2023-04-28)
The melanocortin system comprises the endogenous melanocortin peptides adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormones (α-, β- & γ-MSH) as well as their five cognate receptors (MC1R – MC5R). These ...