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A Systems Biology Analysis of PP2A Functions in Cancer Cells
(Annales Universitatis Turkuensis D 1264Turun yliopisto, 2017-01-20)
Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ...
Regulation of MYC activity by post-translational modifications
(2018-09-21)
MYC is a transcription factor that is often found deregulated in cancer. Post-translational modifications, including phosphorylation and ubiquitination, play important role in controlling MYC expression and activity.
This ...
Histological detection and prognostic value of regulators of metaphase-anaphase transition in breast cancer
(Turun yliopisto, 2018-12-14)
The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...
Securin-related cell proliferation in breast cancer prognosis
(Turun yliopisto, 2020-03-13)
Breast cancer is the most common malignancy among women. It remains a major cause of mortality among women, although the five-year survival of breast cancer patients is about 90%. To aid in the clinical treatment decisions, ...
Biomarkers in stage II colorectal cancer
(Turun yliopisto, 2020-02-21)
The risk of recurrence of stage II colorectal cancer is difficult to predict. A part of recurrences take place among patients without any of the known high-risk factors such as lymphovascular invasion or preoperative ...
The Role of PME-1 in Cancer: Therapeutic Implication
(Annales Universitatis Turkuensis D 1238Turun yliopisto, 2016-08-19)
Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis in human cells by reversibly affecting the phosphorylation of a variety of proteins. Protein phosphatase ...
Epidermal growth factor receptor and other tissue biomarkers in gastrointestinal cancers
(Turun yliopisto, 2019-11-01)
Personalised medicine has plays an increasing role in the treatment of cancer. New therapeutic molecules are being developed, but their compatibility for each patient has to be tested before starting the treatment by ...
B Cell Activation and Antibody Responses: The role of vesicle trafficking and Rab GTPases
(Turun yliopisto, 2022-08-12)
B lymphocytes are an important part of the adaptive immune system. As one of their main functions, B cells can recognise specific antigens via their B cell receptor and produce antibodies that help clear infections. In ...
B cell-mediated immunity and signal regulation. The roles of MIM/MTSS1 and IRF4
(Turun yliopisto, 2022-03-11)
B cells constitute an important part of the adaptive immune system and produce antibodies, which protect organism against infectious agents. Recognition of the antigen by the B cell receptor and the following B cell ...
Cellular vulnerabilities of glioblastoma
(Turun yliopisto, 2021-10-15)
Glioblastoma (GB) is the most fatal and frequent malignant brain tumor, and it is driven by multiple oncogenic pathways. Despite intensive screening of genomic, transcriptomic, metabolic, and post-translational landscape ...