Hae
Aineistot 231-240 / 629
IMAGE DERIVED INPUT FUNCTION FOR BRAIN [11C]TMSX PET IMAGING
(2019-04-05)
Modeling and analysis of positron emission tomography (PET) imaging data requires the critical information of the input function of the radioligand used. In PET imaging of the brain, the ‘gold standard’ for acquiring input ...
Assay development and study of a mutation affecting gonadotropin action
(Annales Universitatis Turkuensis D 1246Turun yliopisto, 2016-09-23)
The gonadotropin action mediated via three glycoprotein hormones, luteinizing hormone (LH), chorionic gonadotropin (CG) and follicle-stimulating hormone (FSH) is paramount for sexual differentiation, pubertal development ...
Targeting Somatostatin Receptors with Peptide-functionalized Silica Nanoparticles
(Turun yliopisto, 2021-08-25)
ABSTRACT
Nano-sized synthetic drug carriers comprise a valuable addition to oncology armaments, opening new avenues for improved delivery of anticancer therapies. Nanocarriers designed to bind surface receptors of tumor ...
Neural Structures Associated with Music Engagement in Persons with Alzheimer’s Disease
(2020-06-01)
Alzheimer’s disease (AD) is the most common cause of dementia and a major public health issue resulting in decreased life expectancy of patients and high societal cost. Medical treatment of AD is palliative in nature as ...
Potential of the Osteoclast’s Proton Pump as a Drug Target in Osteoporosis
(Annales Universitatis Turkuensis D 970Turun yliopisto, 2011-08-19)
Decreasing bone mass during aging predisposes to fractures and it is estimated that every second woman and one in five men will suffer osteoporotic fractures during their lifetime. Bone is an adaptive tissue undergoing ...
Studies on chemoenzymatic synthesis: Lipase-catalyzed acylation in multistep organic synthesis
(Annales Universitatis Turkuensis D 1036Turun yliopisto, 2012-11-30)
In this thesis, biocatalysis is defined as the science of using enzymes as catalysts in
organic synthesis. Environmental aspects and the continuously expanding repertoire of
available enzymes have firmly established ...
Data-independent acquisition mass spectrometry for human gut microbiota metaproteome analysis
(Turun yliopisto, 2022-01-13)
Human digestive tract microbiota is a diverse community of microorganisms having complex interactions between microbes and the human host. Observing the functions carried out by microbes is essential for gaining understanding ...
Protein-encapsulated in mesoporous silica nanoparticles for the the treatment of bacterial biofilms
(2019-05-13)
80% of infections are estimated to be biofilm related, which are extremely resistant to anti-microbials. It remains an unmet need to develop medications to treat biofilms. Currently, there are evolving approaches that use ...
Epidemiology of Cytochrome P450-mediated Drug-Drug Interactions
(Annales Universitatis Turkuensis D 922Turun yliopisto, 2010-10-29)
Drug-drug interactions (DDIs) comprise an important cause of adverse drug reactions leading to excess hospitalizations. Drug metabolism is catalyzed by 75% by cytochrome P450 (CYP) enzymes and thus they are often involved ...
Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(2020-05-06)
The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...