Hae

This thesis focuses on tissue inhibitor of metalloproteinases 4 (TIMP4) which is the newest member of a small gene and protein family of four closely related endogenous inhibitors of extracellular matrix (ECM) degrading ...

Asthma and allergy are common diseases and their prevalence is increasing. One of the hypotheses that explains this trend is exposure to inhalable chemicals such as traffi c-related air pollution. Epidemiological research ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...

Tumor immune evasion, a hallmark of cancer, allows malignant cells to escape immune surveillance and elimination. While immune checkpoint inhibitors, such as anti-PD-1, anti-CTLA-4, and anti-PD-L1 antibodies, have ...

Androgens regulate the growth and development of normal prostate and prostate cancer. Blocking the production and effects of androgens, either by castration or medication, has been the most efficient strategy for treating ...

ABSTRACT Pregnant women with overweight and obesity may exhibit altered circulating lowgrade inflammatory and metabolic profile and gut and vaginal microbiota which may contribute to the development of gestational ...

The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...

Lifestyle habits, including diet and physical activity, that deviate from the recommendations during pregnancy and early childhood may eventually increase the risk for obesity and other lifestyle-related diseases in both ...

Neuropeptide Y (NPY) is a neurotransmitter promoting energy storage by activating Y-receptors and thus affecting food intake, thermogenesis and adipose tissue metabolism. NPY is expressed both in the central and ...

Drug-drug interactions (DDIs) comprise an important cause of adverse drug reactions leading to excess hospitalizations. Drug metabolism is catalyzed by 75% by cytochrome P450 (CYP) enzymes and thus they are often involved ...