Hae
Aineistot 31-40 / 91
Somatostatin neurons in the ventral tegmental area; addiction- and anxiety-related behaviours in mice
(2020-10-16)
Ventral tegmental area (VTA) with diverse cell populations is associated with reward, aversion and motivation. Somatostatin is an endogenous peptide with wide range of physiological functions, which are mediated through ...
High throughput flow cytometry-based drug sensitivity testing for melflufen in multiple myeloma
(2020-09-04)
Multiple myeloma (MM) is a hematological plasma cell malignancy in the bone marrow. Lately, increased knowledge of MM pathogenesis and advances in therapy have improved the survival of MM patients. However, due to the ...
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(2019-05-13)
Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...
Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1
(2018-09-19)
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature and abnormally proliferating blast cells in the patient’s bone marrow and peripheral blood. Despite the mounting ...
Functional Characterization of NF1 Deficient Breast Cancer
(2020-11-16)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1:2,000. NF1 is caused by pathogenic variants of the tumor suppressor gene NF1. The NF1 syndrome increases cancer incidence and is ...
Validation of UBR5 as a novel PIM kinase substrate
(2020-10-21)
The serine/threonine-specific PIM kinases have important roles in regulation of cell proliferation, survival, and motility. UBR5 is an E3 ubiquitin ligase and is involved in the regulation of gene expression, apoptosis, ...
Identifying the issues concerning zeta potential measurements of polymer nanoparticles
(2019-05-13)
Introduction:
Recent polymeric nanoparticle appraisals, formulation and drug delivery strategies have been showed up with remarkable advancement although scientists are still looking forward to better targeted drug ...
Adipose tissue in health and disease – implications to cardiovascular diseases
(2020-11-23)
Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(2021-01-25)
After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...
Development of in vitro test battery to predict toxicity of indoor air
(2019-05-02)
The impurities of the air inside the buildings and the resulting health issues have become an increasing problem. Impurities of indoor air may cause various symptoms, such as respiratory symptoms, nausea, fatigue and memory ...