Hae
Aineistot 31-40 / 55
Molecular dynamics and virtual screening approaches in drug discovery
(Turun yliopisto, 2022-10-28)
Computer-aided drug discovery (CADD) methods are now routinely used in the
preclinical phase of drug development. Powerful high-performance computing
facilities and the extremely fast CADD methods constantly scale up the ...
Characterisation of the role of TLNRD1 in vascular development and integrity in zebrafish
(2022-09-05)
Angiogenesis, the formation of new blood vessels, is an essential process for vascular growth and blood vessel development. Defective regulation and abnormalities of angiogenesis are present in multiple diseases, such as ...
Verenpaineen säätelyn ja kohonneen verenpaineen lääkehoidon opiskelu hyödyntäen interaktiivista H5P-verkkotyökalua
(2022-02-03)
Kohonnut verenpaine on merkittävä terveyteen haitallisesti vaikuttava tekijä. Maailmanlaajuisesti se aiheuttaa eniten terveiden elinvuosien menetystä verrattuna muihin terveydellisiin riskitekijöihin. Yli 30-vuotiaista ...
Auria Biopankin hyödynnettävyys tutkittavien rekrytoinnin apuna kliinisissä lääketutkimuksissa
(Turun yliopisto, 2016-04-26)
Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
Ultrasensitiivisen HIV-1 p24 ELISA-määritysmenetelmän karakterisointi veritäplillä
(Turun yliopisto, 2017-04-04)
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
(Turun yliopisto, 2022-01-21)
The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...
Disruption of Clever-1 for Novel Anticancer Immunotherapy
(Turun yliopisto, 2016-11-22)
The progression of cancer is dependent on the quality of the immune response elicited by the tumour. Typically, proinflammatory immune responses restrain and anti-inflammatory immune responses promote the progression of ...
Cavity-based negative images in molecular docking
(Turun yliopisto, 2021-10-01)
In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ...
Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
(Turun yliopisto, 2017-08-08)
Nitric oxide (NO) is a diatomic gaseous molecule generated in our bodies by enzymes known as NO synthases. More recently another pathway for generation of NO has been delineated in which dietary or endogenous inorganic ...