Hae
Aineistot 31-40 / 66
Äidin raskaudenaikaisen psykologisen stressin yhteys istukan ja napaveren glukokortikoidireseptoria koodaavan geenin DNA-metylaatioon
(2022-04-04)
Raskauden aikana n. 4–20 % naisista on havaittu kärsivän psykologisesta stressistä ja masennusoireista, jotka syntyvät erilaisten haasteiden kohtaamisesta raskauden aikana. Raskaudenaikaiset masennusoireet saattavat vaikuttaa ...
A genome-wide association study of CYP1A2 activity using tizanidine and caffeine as probe drugs
(2022-01-13)
Cytochrome P450 (CYP) enzymes are the major drug metabolizing enzyme group. The highest level of CYPs is expressed in the liver, and the human cytochrome P450 (CYP) 1A2 is one of the major CYPs playing an important role ...
Delivery of Cas9/sgRNA system using functionalized mesoporous silica nanoparticle system
(2020-09-03)
CRISPR/Cas9 has become an attractive tool for performing genomic editing due to its versatility and efficiency. However, one of the major challenges in CRISPR/Cas9-based genome editing is the active delivery to the specific ...
Phylogenomic characterization of flaviviruses
(2019-02-21)
Background: The occurrences of global viral pandemics have been rising as increased travel between distant countries has introduced previously endemic viruses to new envi-ronments. Major contributors to global human ...
Onkolyyttisen, dekoriinia ilmentävän herpesvirusvektorin kehittäminen
(2020-03-26)
Geeniterapialla pyritään hoitamaan sairauksia tai estämään sairauden puhkeaminen siirtämällä terapeuttinen geeni potilaaseen. Siirtogeenin saamiseksi kohdesoluihin tarvitaan vektoreita kuljettimiksi, joihin virukset sopivat ...
Effects of endurance training on capillary density and energy metabolism of the right ventricle of streptozotocin –diabetic swine: the role of HIF and AMPK behind changes
(Turun yliopisto, 2017-09-18)
Diabetes affects 422 million people all over the world. Its special characteristic is hyperglycemia that eventually leads to coronary artery disease and diabetic cardiomyopathy. Exercise training is known to enhance ...
Specific Targeting and Novel Molecular Players in Leukemogenesis Associated with Mutant Nucleophosmin
(2020-05-25)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. In AML, NPM (nucleophosmin) is the most frequently mutated gene. NPM is a nucleolar shuttling protein that interacts with several proteins, and ...
Glyfosaattialtistuksen (Roundup® Flex) vaikutukset japaninviiriäisten (Coturnix japonica) maksaan ja alkioihin
(2019-04-18)
Glyfosaatti on rikkakasvien torjuntaan eniten käytetty tehoaine maailmanlaajuisesti. Glyfosaatin tunnetuin kauppanimi on Roundup, joka on laajakirjoinen ja epäselektiivinen rikkakasvien torjunta-aine. Glyfosaatin käyttö ...
A census analysis of the 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase and EPSP-associated domains
(2020-08-11)
Glyphosate is one of the most used herbicides against weeds that targets the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). EPSPS is the central enzyme in the shikimate pathway to synthesize 3 essential amino ...
Ex vivo assessment of efficacy of targeted therapies for treatment of HER2-positive parotid gland cancer
(2019-04-09)
HER2 (human epidermal growth factor receptor 2) positive salivary gland carcinomas are extremely rare with incidence lower than 1 % of all cancers worldwide. Unlike other salivary gland neoplasms, HER2+ salivary gland ...