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In Search of Ebola Virus Glycoprotein Inhibitors: A Structure-Based Drug Design Study
(2021-03-05)
Ebola virus (EBOV) is one of the deadliest viruses that causes haemorrhagic fever in humans and the fatality rate is more than 50%. The biggest outbreak of Ebola virus disease (EVD) occurred in 2014-2016 in West Africa ...
Investigation of molecular interactions of prenylflavonoids at GABAA receptor subtypes
(2019-05-23)
Prenylated flavonoids derived from Hops (Humulus lupulus) activate the γ-aminobutyric acid (GABA) type A receptors through positive and negative modulation. Currently, these compounds’ binding site at the different GABAAR ...
Inhibition of the Nonessential Neurovirulence Gene of Herpes Simplex Virus Type 1 Using RNA Interference
(2021-05-04)
Herpes simplex virus type 1 (HSV-1) is a common pathogen that causes recurrent and latent infections in humans. The nonessential neurovirulence gene γ134.5 prevents cellular responses to an infection in differentiated host ...
FTIR and Raman spectroscopy in characterization of bioreactor cultured prostate cancer extracellular vesicles
(2021-03-15)
Background: Extracellular vesicles (EVs) are nano-sized cell membrane derived structures that function as intercellular messengers and hold potential for applications in diagnostics and drug delivery. There is a need to ...
Role of G-quadruplexes in targeting of somatic hypermutation
(2021-05-26)
Formation of high-affinity antibodies towards antigens is ensured with a process called somatic hypermutation, which happens during affinity maturation of activated B-cells. During this process point mutations are introduced ...
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(2021-09-14)
Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...
Initiation of New Medication With an Actionable Pharmacogenetics-Based Prescribing Guideline in Discharged Hospital Patients in Finland
(2021-05-07)
OBJECTIVES. Purpose of this retrospective, register-based pharmacoepidemiologic study was to analyse post-discharge purchases of drugs with an actionable pharmacogenetics-based prescribing guideline with a patient cohort ...
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(2021-05-10)
Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...
Mechanisms of aging induced decline in wound healing
(2020-09-22)
The impaired wound healing is a significant concern affecting millions of people worldwide. The increased incidence is mainly caused by growing number of aged individuals, whose potential to repair tissues and healing of ...
Exercise-induced mobilization of white blood cells in breast cancer patients
(2023-04-24)
Acute exercise causes mobilization of the immune cells in healthy individuals, but the phenomenon is less investigated in cancer patients. Exercise-induced mobilization of leukocytes may have positive effects in cancer ...