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The Role of c-Abl Kinase in Cancer Cells Sensitivity to Mitoxantrone
(Turun yliopisto, 2018-07-09)
Triple-negative breast cancer (TNBC) is a cancer sub-type with poor prognosis and it lacks targeted therapies. The c-Abl is a non-receptor tyrosine kinase as well as a proto-oncoprotein. It has a role in DNA damage cascade ...
Role of PIM kinase-mediated regulation of Notch3 receptor protein in breast cancer
(Turun yliopisto, 2018-07-09)
In Vitro α-synuclein aggregation assay for studying induced cellular stress, drug targets and compounds
Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...
The role of the GABAA receptor δ subunit domains on agonist binding kinetics
The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...
The Antigen Processing Pathway in B Cells Utilizes Peripheral Endocytic Recycling Compartments
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as antigen presenting cells: they internalize protein antigens and process them into peptides for presentation on Major ...
In vitro evaluation of nanoantibiotics
The discovery of antibiotics made a significant difference in human mortality by considerably reducing the number of deaths caused by infections. Over the years, the bacteria gradually developed resistance against available ...
Dietary Intake in Relation to the Risk of Developing Gestational Diabetes
BACKGROUND Gestational diabetes (GDM) may predispose both the mother and her child to unfavorable health effects. Previous studies indicate that early pregnancy diet could explain the development of GDM in late pregnancy, ...
Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...
Investigation of molecular interactions of prenylflavonoids at GABAA receptor subtypes
Prenylated flavonoids derived from Hops (Humulus lupulus) activate the γ-aminobutyric acid (GABA) type A receptors through positive and negative modulation. Currently, these compounds’ binding site at the different GABAAR ...
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...