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Aineistot 1-9 / 9
Effect of melanocortin-1 receptor in the regulation of beta3-adrenoceptor agonist-induced BAT thermogenesis
(Turun yliopisto, 2019-03-01)
Adipose tissue is comprised of brown and white adipose tissues. In particular, brown adipose tissues (BAT) or brown fat contain rich amount of beta3-adrenoceptors (β3AR) and they are regulated by sympathetic nervous system ...
Differentiation of Metabolically Distinct Areas within Head and Neck Region using Dynamic 18F-FDG Positron Emission Tomography Imaging
(Turun yliopisto, 2014-01-28)
Positron Emission Tomography (PET) using <sup>18</sup>F-FDG is playing a vital role in the diagnosis and treatment planning of cancer. However, the most widely used radiotracer, <sup>18</sup>F-FDG, is not specific for ...
Disruption of Clever-1 for Novel Anticancer Immunotherapy
(Turun yliopisto, 2016-11-22)
The progression of cancer is dependent on the quality of the immune response elicited by the tumour. Typically, proinflammatory immune responses restrain and anti-inflammatory immune responses promote the progression of ...
Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
(Turun yliopisto, 2017-08-10)
Nitric oxide (NO) is a diatomic gaseous molecule generated in our bodies by enzymes known as NO synthases. More recently another pathway for generation of NO has been delineated in which dietary or endogenous inorganic ...
The effects of transgenic melanocortin overexpression in atherosclerotic mice
(Turun yliopisto, 2016-12-14)
Atherosclerosis is a chronic inflammatory disease of the arteries and a common cause of death worldwide. The disease is initiated by endothelial dysfunction that allows the transport of leukocytes and ...
Optimization of immunofluorescence protocols for detection of biomarkers in colorectal and breast cancer tissues
(Turun yliopisto, 2016-06-06)
Cancer remains an undetermined question for modern medicine. Every year millions of people ranging from children to adult die since the modern treatment is unable to meet the challenge. Research must continue in the ...
The Role of Beta Subunit Variant on the Properties of Delta-Containing Extrasynaptic GABAA Receptors
(Turun yliopisto, 2017-08-10)
Muscimol, a psychoactive constituent of Amanita muscaria, activates all GABAA receptor subtypes with exceptionally high affinity to αβδ. This is explained by δ subunit role on muscimol extremely slow dissociation from these ...
Auria Biopankin hyödynnettävyys tutkittavien rekrytoinnissa kliinisiin lääketutkimuksiin
(Turun yliopisto, 2016-08-19)
Kliininen lääketutkimus on ihmiseen kohdistuva interventiotutkimus, jonka tavoitteena on selvittää lääkeaineiden farmakodynaamisia sekä farmakokineettisiä ominaisuuksia ihmiselimistössä. Tutkittavien rekrytointi ...
The effect of melanocortin-1 receptor deficiency on cholesterol transporter genes in atherosclerotic ApoE knockout mouse model
(Turun yliopisto, 2017-07-20)
The melanocortin system comprises of melanocortin peptides; α-, β- and γ- melanocortin stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) derived from the proteolytic degradation ...