Viimeksi syötetyt

Aineistot 10681-10700 / 58417

    • Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing 

      Ashraf, Muhammad Waqar; Poikola, Satu; Neuvonen, Mikko; Kiiski, Johanna I.; Kontinen, Vesa K.; Olkkola, Klaus T.; Backman, Janne T.; Niemi, Mikko; Saari, Teijo I.
      <p><strong>Background and Objective</strong> Codeine metabolism in humans is complex due to the involvement of multiple cytochrome P450 (CYP) enzymes, and has a strong genetic underpinning, which determines the levels of ...

    • Norwegian nurse educators' self-rating of competencies : a nationwide cross-sectional web-survey 

      Gonzalez Marianne Thorsen; Bakken Linda Nilsen; Horntvedt May-Elin T.; Hofoss Dag; Salminen Leena
      <p>Background<br>Nurse educators’ competencies play a crucial role in the educational quality of nurses.</p><p>Objective<br>This study aimed to investigate how Norwegian nurse educators self-rated their competence domains, ...

    • Energy economy in Cuba and future challenges 

      Saunders Vázquez Anaely; Kaivo-oja Jari; Luukkanen Jyrki
      FFRC eBooks

    • Burden of Modifiable Risk Factors in Young : Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale 

      Putaala, Jukka; Martinez-Majander, Nicolas; Leppert, Michelle; Tulkki, Lauri; Pirinen, Jani; Tolppanen, Heli; Sarkanen, Tomi; Virtanen, Marko; Jaakonmäki, Nina; Jäkälä, Pekka; Hedman, Marja; Redfors, Petra; Bech-Hanssen, Odd; Junttola, Ulla; Huhtakangas, Juha; Ylikotila, Pauli; Lautamäki, Riikka; Schminke, Ulf; Von Sarnowski, Bettina; Busch, Raila; Yesilot, Nilüfer; Sezgin, Mine; Waje-Andreassen, Ulrike; Saeed, Sahrai; Fonseca, Ana Catarina; Paula, André; Amaya Pascasio, Laura; Martínez-Sánchez, Patricia; Kõrv, Janika; Muda, Piibe; Ferdinand, Phillip; Oxley, Cheryl; Zakarkaitė, Diana; Ryliškienė, Kristina; Pezzini, Alessandro; Lombardi, Carlo Mario; Licenik, Radim; Zedde, Marialuisa; Grimaldi, Teresa; Tsivgoulis, Georgios; Sinisalo, Juha; Gerdts, Eva; Tatlisumak, Turgut; SECRETO Study Group
      <p><strong>BACKGROUND</strong>:<br>The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations ...

    • A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer 

      Song RJ; Guo PL; Ren X; Zhou LJ; Li P; Rahman NA; Wolczynski S; Li XR; Zhang YJ; Liu M; Liu JL; Li XD
      <p><strong>Background: </strong>The treatment of Triple-negative breast cancer (TNBC) has always been challenging due to its heterogeneity and the absence of well-defined molecular targets. The present study aims to elucidate ...

    • Childhood trauma and fear of childbirth: findings from a birth cohort study 

      Porthan Elviira; Lindberg Matti; Härkönen Juho; Scheinin Noora M; Karlsson Linnea; Karlsson Hasse; Ekholm Eeva
      The aim of this study is to investigate if experiencing childhood trauma (emotional abuse, emotional neglect, physical abuse, physical neglect, or sexual abuse) or a greater total burden of childhood trauma increase the ...

    • Strong Neutralizing Antibody Responses to SARS-CoV-2 Variants Following a Single Vaccine Dose in Subjects With Previous SARS-CoV-2 Infection 

      Ekström Nina; Haveri Anu; Solastie Anna; Virta; Camilla; Österlund Pamela; Nohynek Hanna; Nieminen Tuomo; Ivaska Lauri; Tähtinen Paula A.; Lempainen Johanna; Jalkanen Pinja; Julkunen Ilkka; Palmu Arto A.; Melin Merit
      <p><strong>Background: </strong>Previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primes the immune system; thus individuals who have recovered from infection have enhanced immune responses ...

    • Lämmön merkitys varhaiskasvatuksessa: Kysymyksiä ja ehdotuksia opettajankoulutukselle 

      Jännetyinen, Jukka; Sintonen, Sara; Korhonen, Riitta
      <p>Tässä katsauksessa tuomme esille lämmön tematiikan ja pohdimme sitä erityisesti suhteessa varhaiskasvatuksen opettajan ammatillisuuteen sekä varhaiskasvatuksen opettajankoulutukseen. Käytämme termiä "lämpö kuvaamaan ...

    • Mitähän professori Riker sanoisi tänään? – Politiikan teorian ja sosiaalisen valinnan jälleennäkeminen 

      Hannu Nurmi
      Reports from the Department of Philosophy, University of Turku

    • Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis 

      Vedantham, Madhukar; Polari, Lauri; Poosakkannu, Anbu; Pinto, Rita G.; Sakari, Moona; Laine, Jukka; Sipilä, Petra; Määttä, Jorma; Gerke, Heidi; Rissanen, Tiia; Rantakari, Pia; Toivola, Diana M.; Pulliainen, Arto T.
      Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP-ribose) polymerase 14 (Parp14), an important ...

    • Deep phenotyping of patients with MASLD upon high-intensity interval training 

      Houttu, Veera; Boulund, Ulrika; Troelstra, Marian; Csader, Susanne; Stols-Gonçalves, Daniela; Mak, Anne Linde; van Dijk, Anne-Marieke; Bouts, Julia; Winkelmeijer, Maaike; Verdoes, Xanthe; van den Berg-faay; Sandra; Lek, Donne; Ronteltap, Ted; de Haan, Ferdinand; Jorstad, Harald; Männistö, Ville; Savonen, Kai; Pentikäinen, Heikki; Hanhineva, Kati; Babu, Ambrin Farizah; Panagiotou, Gianni; van Delden, Otto; Verheij, Joanne; Doukas, Michial; Nederveen, Aart; Schwab, Ursula; Grefhorst, Aldo; Nieuwdorp, Max; Holleboom, Adriaan Georgius
      <h3>Background & Aims</h3><p><br></p><p>Exercise is a key component of lifestyle management in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but neither its therapeutic effect on the active ...

    • In vitro model of bone to facilitate measurement of adhesion forces and super-resolution imaging of osteoclasts 

      Deguchi T; Alanne MH; Fazeli E; Fagerlund KM; Pennanen P; Lehenkari P; Hanninen PE; Peltonen J; Nareoja T
      <p> To elucidate processes in the osteoclastic bone resorption, visualise resorption and related actin reorganisation, a combination of imaging technologies and an applicable in vitro model is needed. Nanosized bone ...

    • Feasibility of shortening scan duration of 18F-FDG myocardial metabolism imaging using a total-body PET/CT scanner 

      Zhang, Xiaochun; Xiang, Zeyin; Wang, Fanghu; Han, Chunlei; Zhang, Qing; Liu, Entao; Yuan, Hui; Jiang, Lei
      <p><strong>Purpose:</strong> <br></p><p>To evaluate <sup>18</sup>F-FDG myocardial metabolism imaging (MMI) using a total-body PET/CT scanner and explore the feasible scan duration to guide the clinical practice. ...

    • Managing Positive Change: Emotions and Communication Following Acquisitions 

      Harikkala-Laihinen Riikka
      <p>This article takes a positive organizational scholarship lens to change management and explores what is the relationship between emotions and communication in managing positive change. Through an abductive study, it ...

    • The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression 

      Saarikettu Juha; Lehmusvaara Saara; Pesu Marko; Junttila Ilkka; Partanen Juha; Sipilä Petra; Poutanen Matti; Yang Jie; Haikarainen Teemu; Silvennoinen Olli
      Snd1 is an evolutionarily conserved RNA-binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the ...

    • Barriers to vaccine acceptance in the adult population of mainland Finland, 2021 

      Lasander, Mervi; Elo, Kimmo; Joronen, Katja; Dub, Timothée
      <p> There has been a lack of information on vaccine acceptance for Finnish adults. We conducted a secondary analysis of cross-sectional data collected through the Finnish Medicines Agency Medicine Barometer 2021 survey ...

    • Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities 

      Sousa-Pinto Bernardo; Anto Aram; Berger Markus; Dramburg Stephanie; Pfaar Oliver; Klimek Ludger; Jutel Marek; Czarlewski Wienczyslawa; Bedbrook Anna; Valiulis Arunas; Agache Ioana; Amaral Rita; Ansotegui Ignacio J.; Bastl Katharina; Berger Uwe; Bergmann Karl C.; Bosnic-Anticevich Sinthia; Braido Fulvio; Brussino Luisa; Cardona Victoria; Casale Thomas; Canonica G. Walter; Cecchi Lorenzo; Charpin Denis; Chivato Tomás; Chu Derek K.; Cingi Cemal; Costa Elisio M.; Cruz Alvaro A.; Devillier Philippe; Durham Stephen R.; Ebisawa Motohiro; Fiocchi Alessandro; Fokkens Wytske J.; Gemicioğlu Bilun; Gotua Maia; Guzmán Maria-Antonieta; Haahtela Tari; Ivancevich Juan Carlos; Kuna Piotr; Kaidashev Igor; Khaitov Musa; Kvedariene Violeta; Larenas-Linnemann Désirée E.; Lipworth Brian; Laune Daniel; Matricardi Paolo M.; Morais-Almeida Mario; Mullol Joaquim; Naclerio Robert; Neffen Hugo; Nekam Kristoff; Niedoszytko Marek; Okamoto Yoshitaka; Papadopoulos Nikolaos G.; Park Hae-Sim; Passalacqua Giovanni; Patella Vincenzo; Pelosi Simone; Pham-Thi Nhân; Popov Ted A.; Regateiro Frederico S.; Reitsma Sietze; Rodriguez-Gonzales Monica; Rosario Nelson; Rouadi Philip W.; Samolinski Boleslaw; Sá-Sousa Ana; Sastre Joaquin; Sheikh Aziz; Ulrik Charlotte Suppli; Taborda-Barata Luis; Todo-Bom Ana; Tomazic Peter Valentin; Toppila-Salmi Sanna; Tripodi Salvatore; Tsiligianni Ioanna; Valovirta Erkka; Ventura Maria Teresa; Valero Antonio A.; Vieira Rafael José; Wallace Dana; Waserman Susan; Williams Sian; Yorgancioglu Arzu; Zhang Luo; Zidarn Mihaela; Zuberbier Jaron; Olze Heidi; Antó Josep M.; Zuberbier Torsten; Fonseca João A.; Bousquet Jean
      <p>Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. ...

    • The silent trauma: U.S. immigration policies and mental health 

      Dadras, Omid; Hazratzai, Mohammad Sediq

    • La conscience métapragmatique et l’attitude métacognitive épistémique des scripteurs universitaires : la révision de texte en temps réel 

      Maarit Mutta
      <p>Cet article vise à explorer la conscience métapragmatique des scripteurs universitaires lors d’une tâche de révision en temps réel. Le cadre théorique puise dans les travaux sur les processus cognitifs et dans les ...

    • Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma 

      Koskenniemi, A.R.; Huusko, T.; Routila, J.; Jalkanen, S.; Hollmén, M.; Vainio, P.; Ventelä, S.
      <p><strong>Objective:</strong> <br></p><p>Despite growing interest in neoadjuvant therapies, there are no methods to predict radio- (RT) or chemoradiotherapy (CRT) response in head and neck squamous cell carcinoma (HNSCC). ...