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Aineistot 1-10 / 21
Tools and strategies for RNA-sequencing data analysis
(Turun yliopisto, 2023-08-25)
RNA-Sequencing (RNA-seq) has enabled the in-depth study of the transcriptome, becoming the primary research method in the field of molecular biology. The typical aim of RNA-seq is to quantify and detect differentially ...
Developmental aspects of male reproductive health: clinical studies on semen quality, cryptorchidism, and puberty
(Turun yliopisto, 2023-08-11)
Current evidence shows increasing rates of male reproductive disorders, including cryptorchidism, hypospadias, poor semen quality, decreased testosterone level, and testicular cancer. Therefore, studies on the physiology ...
Clinical studies on testicular growth and descent
(Turun yliopisto, 2018-02-02)
Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...
Regulation of human aromatase gene expression in adipose tissue
(2020-02-29)
The conversion of androgens to estrogens is catalyzed by the aromatase enzyme, the product of the CYP19A1 gene, in gonads and peripheral tissues. Estrogens produced in the white adipose tissue (WAT) are postulated to play ...
Androgen receptor therapy resistance in prostate cancer: From the disease model to the mechanisms
(Turun yliopisto, 2024-03-08)
Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in ...
HSD17BS in steroid and lipid metabolism and lipid disorders: the role of HSD17B12 and HSD17B13
(Turun yliopisto, 2023-10-27)
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of fat within hepatocytes, has become the most common chronic liver disease in developed countries. NAFLD is associated with insulin ...
Targeting Somatostatin Receptors with Peptide-functionalized Silica Nanoparticles
(Turun yliopisto, 2021-08-25)
ABSTRACT
Nano-sized synthetic drug carriers comprise a valuable addition to oncology armaments, opening new avenues for improved delivery of anticancer therapies. Nanocarriers designed to bind surface receptors of tumor ...
ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models
(Turun yliopisto, 2018-06-15)
Abstract:
Prostate cancer is a major global challenge due to the increasing number of aging population
and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic
prostate cancer is responsive ...
Old acquaintances and new perspectives into testicular development and function
(Turun yliopisto, 2020-11-27)
Testicular development and function are complex processes that involve synchronization of the proliferation, apoptosis, and differentiation of specific somatic and germ cells to ensure lifelong fertility. Dysregulation of ...
The role of HSD17B3 in male development and health: Disruption of testosterone production and its effects
(Turun yliopisto, 2024-10-04)
ABSTRACT
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme converting androstenedione (A) to testosterone (T) in human and mouse testes. It is therefore important for male development ...