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RNA-Sequencing (RNA-seq) has enabled the in-depth study of the transcriptome, becoming the primary research method in the field of molecular biology. The typical aim of RNA-seq is to quantify and detect differentially ...

Current evidence shows increasing rates of male reproductive disorders, including cryptorchidism, hypospadias, poor semen quality, decreased testosterone level, and testicular cancer. Therefore, studies on the physiology ...

Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...

The conversion of androgens to estrogens is catalyzed by the aromatase enzyme, the product of the CYP19A1 gene, in gonads and peripheral tissues. Estrogens produced in the white adipose tissue (WAT) are postulated to play ...

Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in ...

ABSTRACT Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of fat within hepatocytes, has become the most common chronic liver disease in developed countries. NAFLD is associated with insulin ...

ABSTRACT Nano-sized synthetic drug carriers comprise a valuable addition to oncology armaments, opening new avenues for improved delivery of anticancer therapies. Nanocarriers designed to bind surface receptors of tumor ...

Abstract: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic prostate cancer is responsive ...

Testicular development and function are complex processes that involve synchronization of the proliferation, apoptosis, and differentiation of specific somatic and germ cells to ensure lifelong fertility. Dysregulation of ...

ABSTRACT Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme converting androstenedione (A) to testosterone (T) in human and mouse testes. It is therefore important for male development ...