Hae

Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome caused by mutations in the large and complex NF1 tumor suppressor gene on chromosome 17. NF1 is the most frequent hereditary tumor predisposition syndrome. ...

Sharpin (SHANK‐Associated RH Domain Interactor) is a multifunctional adaptor protein that interacts with other proteins and regulates their functions. For example, Sharpin is a subunit of the linear ubiquitination assembly ...

ABSTRACT In this thesis, a novel method to determine a chemical fingerprint for liquids was developed and it’s performance was studied in real world applications. The fingerprints are generated from interactions between ...

Filopodia are actin-rich cell protrusions that are extended from the plasma membrane by different cell types in order to sense the surrounding environment. In cancer cells, the emergence of filopodia supports metastasis, ...

Advanced, metastatic stages of breast cancer are associated with high morbidity and mortality, and there is a need to establish a proof-of-concept for novel compounds that can change this scheme. Fibroblast growth factors ...

Toll-like receptor 9 (TLR9) is an endosomal innate immunity receptor that plays a vital role in the first line of defense, primarily in immune cells, but in varying degrees, also in other non-immune tissues. Once TLR9 ...

Bone is an active tissue that undergoes constant remodelling. Bone-forming osteoblasts use various energy sources to meet their energy demand, and one of the main energy sources of the cells is glucose. Glucose is transferred ...

During this study, advances in bioimaging have affected the biomedical research field. In this thesis, traditional microscopy and selected new techniques, namely microcomputed tomography (µCT), STED microscopy and ...

CD73 is a membrane-bound receptor that converts AMP to adenosine. Its overexpression in tumors is associated with poor outcomes in triple-negative breast cancer (TNBC) patients. TNBC patients have limited treatment options ...

In order to form tissues and to move, cells need to attach to the surrounding environment. Integrins are the major cell adhesion receptors that cells use to attach to the extracellular matrix on the outside of the cell, ...