Hae

Antiviral nucleosides are compounds that are used against viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV). To act as therapeutic agent, the antiviral nucleoside needs to be phosphorylated ...

Upconversion luminescence where visible light can be obtained through low energy near-infrared radiation is an interesting research topic especially within the scope of biomedical applications using optical detection. The ...

Positron emission tomography (PET) is a sensitive and non-invasive molecular imaging modality with various applications, including drug discovery and the development of novel therapeutics evaluation at an early stage. ...

Chlorambucil is an anticancer agent used in the treatment of a variety of cancers, especially in chronic lymphocytic leukemia, and autoimmune diseases. Nevertheless, chlorambucil is potentially mutagenic, teratogenic and ...

The chemical diversity of plants is enormous as plants produce a variety of compounds that play key roles, for instance, in the growth, defence and reproduction of plants. This diversity is not well recognised in chemistry ...

Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...

Dynamic combinatorial chemistry (DCC) has emerged as a powerful tool for screening and optimization of lead compounds for the discovery of new drugs. This thesis introduces a novel method for base filling through the ...

Bringing a new drug to the market is an expensive and long process. Typically, more than ten years and a billion dollars needs to be spent so the whole process is a big investment for a pharma company. The hit generation ...

The smectites represent a versatile class of clay minerals, offering possibilities of applications in several industrial and scientific fields. The hectorite belongs to this class, but it has the advantage of production ...

This thesis work focused on a specialized plant metabolite group called hydrolysable tannins with the aim of expanding the knowledge on their hydrophobicity, interactions with lipid membranes and antibacterial capacity. ...