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Distribution and oxidative activities of phenolic compounds in the plant kingdom
(Turun yliopisto, 2020-12-08)
Plant phenolics have been studied for decades because of their role as chemodefensive compounds against herbivores and pathogens, and their assumed health benefits to humans. One of their proposed modes of actions is ...
Organomercury oligonucleotides as artificial ribonucleases
(Turun yliopisto, 2024-05-10)
Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...
Tuning Photochromic Sodalites across the Visible Spectrum
(Turun yliopisto, 2023-06-16)
Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...
The peptide-break technology : a novel approach for protein post-translational modification assays in drug discovery
(Turun yliopisto, 2019-03-15)
The work presented in this thesis describes the development of a universal platform for the biochemical detection of protein post-translational modifications (PTM) using the quenching resonance energy transfer (QRET) ...
Phenolics of the Inner Bark of Silver Birch: Characterization and Intraspecific Variation
(Turun yliopistoAnnales Universitatis Turkuensis A I 477, 2013-12-13)
This thesis describes work related to the in-depth characterization of the phenolic compounds of silver birch (Betula pendula) inner bark. Phenolic compounds are the most ubiquitous class of plant secondary compounds. The ...
Synthesis of 18F-labelled radiopharmaceuticals for CNS imaging : From radiosynthesis development to GMP production
(Turun yliopisto, 2021-03-19)
Positron emission tomography (PET) is an imaging technique that can be used to follow various biological processes, such as receptor function, in a living body. PET utilisesradiopharmaceuticals, tracers containing short-lived ...
Photoluminescence quenchers in drug discovery
(Turun yliopisto, 2021-12-03)
During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ...
Tautomerism and Fragmentation of Biologically Active Hetero Atom (O, N)-Containing Acyclic and Cyclic Compounds Under Electron Ionization
(Turun yliopistoAnnales Universitatis Turkuensis A I 392, 2009-04-17)
In this thesis a total of 86 compounds containing the hetero atoms oxygen and nitrogen were studied under electron ionization mass spectrometry (EIMS). These compounds are biologically active and were synthesized by various ...
Brown algal phlorotannins: Improving and applying chemical methods
(Turun yliopistoAnnales Universitatis Turkuensis AI 381, 2008-02-22)
Phlorotannins are the least studied group of tannins and are found only in brown algae. Hitherto the roles of phlorotannins, e.g. in plant-herbivore interactions, have been studied by quantifying the total contents of the ...
Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns
(Turun yliopistoAnnales Universitatis Turkuensis A I 494, 2014-11-07)
Ribonucleic acid (RNA) has many biological roles in cells: it takes part in coding, decoding, regulating and expressing of the genes as well as has the capacity to work as a catalyst in numerous biological reactions. These ...