Selaus oppiaineen mukaan kokoelmassa 1. Kirjat ja opinnäytteetDrug Discovery and Development
Aineistot 21-40 / 92
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Development of RT-PCR based method for genome amplification of human picornaviruses and rescue of viable viruses
(27.04.2023)Picornaviruses (family Picornaviridae), causing diseases form respiratory illness to life-threatening CNS disease, are among the most common human pathogens. More than 300 human picornavirus types have been currently ...avoin -
Dietary Intake in Relation to the Risk of Developing Gestational Diabetes
(17.04.2020)BACKGROUND Gestational diabetes (GDM) may predispose both the mother and her child to unfavorable health effects. Previous studies indicate that early pregnancy diet could explain the development of GDM in late pregnancy, ...suljettu -
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(30.11.2021)BACKGROUND Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...avoin -
DNA repair genes in prostate cancer : the characterization of novel molecular mechanisms
(18.05.2020)Prostate cancer is one of the major causes of cancer-related deaths in males in Western countries. Androgen deprivation therapy is a standard treatment for metastatic prostate cancer, aiming to suppress androgen receptor ...suljettu -
Effectiveness and drug survival of biologic drugs in the treatment of juvenile idiopathic arthritis
(03.05.2021)Data on treatment performance in real-life setting is needed to supplement the data gained in randomised clinical trials. Variety of registries are increasingly exploited to provide real-world data on effectiveness and ...suljettu -
Effects of 27-hydroxycholesterol on oligodendrocytes in Alzheimer’s disease: a double-edged sword?
(04.05.2020)Hypercholesterolemia is an established risk factor for developing Alzheimer’s disease (AD). A proposed link between elevated systemic cholesterol levels and AD is oxysterols: oxidized metabolites of cholesterol, which can ...suljettu -
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(25.01.2021)After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...avoin -
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
(05.02.2019)Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...avoin -
Establishment of in vitro breast cancer bone metastasis model using an artificial microenvironment
(11.03.2021)Advanced breast cancer frequently metastasises to the bone, causing considerable morbidity to the patients. Survival rate after detection of bone metastases is poor, and options to treat bone metastases are insufficient. ...avoin -
Ex vivo characterization of joint innervating neurons in osteoarthritic rodent pain model
(28.08.2023)Osteoarthritis (OA) is the most common joint disease worldwide, affecting an estimate of 240 million people. The predominant symptom of OA is pain. Pain perception arises from nociceptive signals in the periphery, that ...suljettu -
Exercise-induced mobilization of white blood cells in breast cancer patients
(24.04.2023)Acute exercise causes mobilization of the immune cells in healthy individuals, but the phenomenon is less investigated in cancer patients. Exercise-induced mobilization of leukocytes may have positive effects in cancer ...suljettu -
Farmakokineettisten geenimuunnosten vaikutus liitännäislääkehoitona annetun dosetakselin aiheuttaman neutropenian riskiin ja hoidon tehoon suomalaisilla rintasyöpään sairastuneilla naisilla
(04.10.2018)Rintasyöpä on naisten yleisin syöpätyyppi ja Suomessa siihen sairastui vuonna 2015 yli 5000 naista. Suuri osa rintasyöpään sairastuneista saa leikkauksen jälkeen riskiarvion mukaan liitännäishoitona lääke- tai/ ja sädehoitoa. ...suljettu -
FTIR and Raman spectroscopy in characterization of bioreactor cultured prostate cancer extracellular vesicles
(15.03.2021)Background: Extracellular vesicles (EVs) are nano-sized cell membrane derived structures that function as intercellular messengers and hold potential for applications in diagnostics and drug delivery. There is a need to ...avoin -
Functional characterization of a humanized anti-Clever-1 antibody targeting monocytes and anti-inflammatory macrophages
(29.11.2018)Targeting the immunosuppressive tumor microenvironment has gained interest in opening new avenues to fight against cancer growth. Macrophages are extremely potential candidates for targeted therapies due to their highly ...suljettu -
Functional Characterization of NF1 Deficient Breast Cancer
(16.11.2020)Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1:2,000. NF1 is caused by pathogenic variants of the tumor suppressor gene NF1. The NF1 syndrome increases cancer incidence and is ...suljettu -
Genetic Polymorphisms in TLR2, TLR4, IL-10, and IL-17A: Possible Effect on Pertussis Acellular Vaccine Response
(08.08.2023)Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, is still endemic despite primary vaccination rates of 81% in 2021. Variability toward vaccination response due to genetic polymorphisms has ...suljettu -
High throughput flow cytometry-based drug sensitivity testing for melflufen in multiple myeloma
(04.09.2020)Multiple myeloma (MM) is a hematological plasma cell malignancy in the bone marrow. Lately, increased knowledge of MM pathogenesis and advances in therapy have improved the survival of MM patients. However, due to the ...avoin -
Hippo pathway activity after a peripheral nerve injury
(14.04.2022)Transcriptional mechanisms underlying chronic neuropathic pain are still unclear. However, novel studies have suggested that the Hippo pathway and especially its compartments YAP and TAZ have a role in the pathology of ...avoin -
Identification of RasGEFs counteracting neuronal SynGAP1 function
(11.05.2021)SynGAP syndrome refers to an under-diagnosed group of diseases caused by the mutation of the SynGAP1 gene encoding the predominant synaptic protein SynGAP1. SynGAP1 is a Ras GTPase activating protein that is a major regulator ...suljettu -
Identifying the issues concerning zeta potential measurements of polymer nanoparticles
(13.05.2019)Introduction: Recent polymeric nanoparticle appraisals, formulation and drug delivery strategies have been showed up with remarkable advancement although scientists are still looking forward to better targeted drug ...suljettu