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Aineistot 21-30 / 228
Studies in selectivity of lipases in preparation of cyanohydrins, sugar conjugates and secondary alcohols
(Annales Universitatis Turkuensis D 1136Turun yliopisto, 2014-10-24)
Biocatalysis can be applied in organic synthetic chemistry to counter challenges posed by increased demands towards chemo-, regio- and stereoselectivity, not forgetting the need for greener chemistry. During the last 30 ...
The Effects of Estradiol, Androgens and the Selective Estrogen Modulators: Ospemifene, Raloxifene and Tamoxifen on Explant Cultures of Human Breast Tissue
(Annales Universitatis Turkuensis D 1070Turun yliopisto, 2013-05-03)
The impact of menopausal hormone therapy (MHT) on increasing the risk for breast cancer
(BC) remains controversial. To understand MHT-elicited cellular breast effects and the
potential risks, included with using this ...
Expression and role of decorin in human epithelial cancers - with special reference to bladder, colon and vulva carcinomas
(Turun yliopisto, 2019-05-11)
Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...
Novel regulators of T helper cell differentiation con-tribute to autoimmune inflammation
(Turun yliopisto, 2018-09-14)
T helper cells are critical components of adaptive immune system contributing to self/ nonself-recognition, pathogen elimination and pathogenesis of immune-associated diseases.
Understanding the underlying mechanisms ...
New insights into receptor trafficking in human cancer
(Turun yliopisto, 2018-11-16)
Plasma membrane receptors play an essential role in cancer by regulating cancer-related processes such as cell proliferation and migration in response to cues from the extracellular ligands. Integrins are cell-matrix ...
Studies on the pathogenesis and historical seroprevalence of Lyme borreliosis in Finland
(Turun yliopisto, 2020-03-13)
Lyme borreliosis (LB) is a common tick-borne infectious disease in the Northern Hemisphere. The LB causing Borrelia burgdorferi sensu lato (Borrelia) spirochetes enter the human host via the tick bite. From the initial ...
Regulation of MYC activity by post-translational modifications
(2018-09-21)
MYC is a transcription factor that is often found deregulated in cancer. Post-translational modifications, including phosphorylation and ubiquitination, play important role in controlling MYC expression and activity.
This ...
Role of cancerous inhibitor of protein phosphatase 2A in the regulation of T-cell response
(Turun yliopisto, 2021-12-03)
T helper (Th) cell subsets with distinct functions are a critical component of the adaptive immune system. Th17 cells secrete interleukin 17 (IL-17) and provide host defense against pathogens. However, dysregulated Th17 ...
Alpha- and gamma-melanocyte stimulating hormones in obesity. A study of the key central areas of metabolic regulation
(Annales Universitatis Turkuensis D 1128Turun yliopisto, 2014-09-19)
The melanocortin system is an important regulator of feeding, energy metabolism,and cardiovascular function and it consists of the pro-opiomelanocortin (POMC) derived melanocyte stimulating hormones (α-, β- and γ-MSH) and ...
Histological detection and prognostic value of regulators of metaphase-anaphase transition in breast cancer
(Turun yliopisto, 2018-12-14)
The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...