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ADMET and adverse effects predictive modeling based on FDA-approved drugs Data
(Turun yliopisto, 2017-01-31)
Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and adverse effects determine the success of each drug. These factors play an important role in the late-stage failure of drug candidates and ...
Normalization of Disease Mentions with Convolutional Neural Networks
(2019-05-22)
Normalization of disease mentions has an important role in biomedical natural language processing (BioNLP) applications, such as the construction of biomedical databases. Various disease mention normalization systems have ...
Identification of dephosphorylated sites in the proximity of recurrent mutations in PP2A targets
(2018-12-12)
Protein Phosphatase 2A (PP2A), a major serine/threonine phosphatase, is known to be involved in the wide range of cellular functions in many cell types. Notably, PP2A’s tumor suppressor function has a great potential for ...
Annotation of Gyrodactylus salaris transcriptome
(Turun yliopisto, 2016-06-15)
Relationship between organisms within an ecosystem is one of the main focuses in the study of ecology and evolution. For instance, host-parasite interactions have long been under close interest of ecology, evolutionary ...
Molecular modeling studies of Escherichia coli MurA towards novel Mur enzyme inhibitors against resistant bacterial strains
(Turun yliopisto, 2016-12-21)
Currently more and more antibiotics are put into clinical use; meanwhile bacteria also develop diverse antibiotic resistance. MurA, a key enzyme on cell wall precursor biosynthesis pathway, was effectively inhibited by a ...
miRNA data analysis workflow
(2019-08-13)
Micro RNAs (miRNA) have been shown to regulate many biological processes by silencing the expression of their target genes. They are small non-coding RNAs that have been found in all types of organisms from eukaryotes to ...
Immunological interactions of virus peptides at the antigen presenting MHC I proteins
(2018-12-13)
Regarding the recent outbreak of Zika virus (ZIKV) infection, there is an urgent need to develop a preventive or a therapeutic ZIKV vaccine. In this thesis, computational analysis was performed to predict suitable peptide ...
De novo transcriptome assembly and annotation of the isopod Idotea balthica
(Turun yliopisto, 2016-05-24)
The Baltic Sea is a unique environment that contains unique genetic populations. In order to study these populations on a genetic level basic molecular research is needed. The aim of this thesis was to provide a basic ...
Structural modeling and analysis of non-mammalian CA VI
(2020-11-26)
Pentraxins are a family of host defense components of the innate immune system and phylogenetically conserved pattern recognition proteins. The short pentraxins are serum amyloid P component (SAP) and C-reactive protein ...
In silico metabolic modelling of Saccharomyces cerevisiae for the overproduction of succinate using OptKnock and OptGene
(Turun yliopisto, 2016-06-08)
Succinate is a naturally occurring metabolite in organism’s cell and is industrially important chemical with various applications in food and pharmaceutical industry. It is also widely used to produce bio-degradable plastics, ...