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Development of male reproductive health in puberty and young adulthood
(Turun yliopisto, 2018-11-30)
The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
The effect of training background on oxidized lipoprotein lipids and antioxidant capacity in athletes and keep-fit runners
(Turun yliopisto, 2018-12-07)
Background: High-intensity acute exercise is known to induce oxidative stress and may lead to harmful oxidation of lipids, and protein and DNA damage. On the other hand, exercise is known to positively influence risk factors ...
MicroRNA-mediated regulation of mitosis and taxane sensitivity in breast and ovarian cancer
(Turun yliopisto, 2017-11-24)
Taxanes are microtubule targeting chemotherapeutics that block cell division (mitosis) and induce cell death. Taxanes are commonly used in the neoadjuvant chemotherapy for breast and ovarian cancer. However, the patient ...
Clinical studies on testicular growth and descent
(Turun yliopisto, 2018-02-02)
Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
(Turun yliopisto, 2018-01-26)
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroidmetabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed ...
Outcome of Hsd17b1 gene deletion in ovarian and adipose tissue function : alterations resulting from both HSD17B1 enzyme inhibition and the off-target effect on the Naglu gene
(Turun yliopisto, 2018-01-05)
Steroids comprise a group of hormones that are, in the traditional view, secreted by the adrenal cortex, testes and ovaries, as well as the placenta during pregnancy and that reach their target organs via blood circulation. ...
Regulation of gonadal steroid synthesis and reproduction : novel roles of hydroxysteroid (17β) dehydrogenase 1
(Turun yliopisto, 2017-12-15)
Estrogens and androgens are critical regulators of several physiological processes,including development and reproduction. In addition, these hormones play key roles in several physiological complications and diseases, ...
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
(Turun yliopisto, 2018-01-19)
At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ...
Identification of novel genes involved in the pathophysiology of adrenocortical tumorigenesis
(Turun yliopisto, 2017-12-01)
Adrenocortical tumors (ACT) are relatively common, with a prevalence of 6% in the aging population. They can be divided into benign adenomas (ACA) and malignant carcinomas (ACC). Tumors responding to luteinizing hormone ...
ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models
(Turun yliopisto, 2018-06-15)
Abstract:
Prostate cancer is a major global challenge due to the increasing number of aging population
and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic
prostate cancer is responsive ...