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Characterization of Mast Cells in Human Cutaneous Neurofibromas
(2020-03-03)
Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome predisposing to malignancies. Most of the adult NF1 patients exhibit cutaneous neurofibromas (cNFs) which are derived from peripheral nerves in the skin. ...
CD206 in colon cancer
(2020-03-17)
The assessment of immunologic milieu in cancer tissue has proven to be a powerful factor in estimation of disease outcome. The basic idea is to characterize the presence of different immune cell types within tumor tissue. ...
PARP Inhibitors in Prostate Cancer – The Preclinical Rationale and Current Clinical Development
(2020-03-17)
Prostate cancer is the second most commonly diagnosed cancer type in men in the Western world. The majority of prostate cancer patients have a good prognosis, while some prostate cancers advance locally or metastasize. ...
The Antigen Processing Pathway in B Cells Utilizes Peripheral Endocytic Recycling Compartments
(2019-10-24)
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as antigen presenting cells: they internalize protein antigens and process them into peptides for presentation on Major ...
CIP2A pään ja kaulan alueen syöpäsolujen viestinvälityksessä
(2020-03-12)
Onkoproteiini CIP2A estää solujen sisäisen viestinvälityksen kannalta erittäin tärkeää kasvunrajoiteproteiinia PP2A, jolloin useat muut syöpää edistävät proteiinit pääsevät toimimaan. CIP2A on yksi yleisimmistä syövässä ...
Imaging and target screening for novel avenues for psychiatric disorder treatments
(2020-02-18)
The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...
Heterogeenisyys pään ja kaulanalueen kasvaimissa ja STAT3:n aktivaatio CIP2A-PP2A-signalointireitin kautta
(2020-03-12)
Pään ja kaulan levyepiteelikarsinoomat ovat kuudenneksi yleisin syöpään liittyvä kuolinsyy maailmanlaajuisesti. Hoidon suunnittelu perustuu vielä nykypäivänä pääosin TNM-luokitukseen sekä klassisiin kliinisiin piirteisiin. ...
In vitro evaluation of nanoantibiotics
(2020-04-15)
The discovery of antibiotics made a significant difference in human mortality by considerably reducing the number of deaths caused by infections. Over the years, the bacteria gradually developed resistance against available ...
Dietary Intake in Relation to the Risk of Developing Gestational Diabetes
(2020-04-17)
BACKGROUND Gestational diabetes (GDM) may predispose both the mother and her child to unfavorable health effects. Previous studies indicate that early pregnancy diet could explain the development of GDM in late pregnancy, ...
Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
(2019-10-10)
Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...