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Photoluminescence quenchers in drug discovery
(Turun yliopisto, 2021-12-03)
During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ...
Tautomerism and Fragmentation of Biologically Active Hetero Atom (O, N)-Containing Acyclic and Cyclic Compounds Under Electron Ionization
(Turun yliopistoAnnales Universitatis Turkuensis A I 392, 2009-04-17)
In this thesis a total of 86 compounds containing the hetero atoms oxygen and nitrogen were studied under electron ionization mass spectrometry (EIMS). These compounds are biologically active and were synthesized by various ...
Brown algal phlorotannins: Improving and applying chemical methods
(Turun yliopistoAnnales Universitatis Turkuensis AI 381, 2008-02-22)
Phlorotannins are the least studied group of tannins and are found only in brown algae. Hitherto the roles of phlorotannins, e.g. in plant-herbivore interactions, have been studied by quantifying the total contents of the ...
Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns
(Turun yliopistoAnnales Universitatis Turkuensis A I 494, 2014-11-07)
Ribonucleic acid (RNA) has many biological roles in cells: it takes part in coding, decoding, regulating and expressing of the genes as well as has the capacity to work as a catalyst in numerous biological reactions. These ...
Functional disulfide macrocycles from dynamic combinatorial libraries
(Turun yliopisto, 2024-09-09)
Dynamic combinatorial chemistry (DCC) is an ideal tool used to create complex chemical systems, where a variety of components are produced in a combinatorial way by linking building blocks through reversible chemical bonds ...
Characterization and in vitro antiparasitic activities of plant extracts containing natural and modified proanthocyanidins
(Turun yliopisto, 2023-05-05)
This thesis focused on the proanthocyanidins (PAs), a class of plant specialized metabolites that have a wide range of industrial applications. They play a vital role in the production of various food and feed products. ...
Flavonoids and other phenolic compounds: characterization and interactions with lepidopteran and sawfly larvae
(Turun yliopistoAnnales Universitatis Turkuensis A I 496, 2014-11-14)
This thesis focuses on flavonoids, a subgroup of phenolic compounds produced by plants, and how they affect the herbivorous larvae of lepidopterans and sawflies. The first part of the literature review examines different ...
Energy transfer in luminescent lanthanoid chelates
(Turun yliopisto, 2020-05-29)
Luminescent lanthanoid complexes are widely utilized, especially in the medical diagnostics. The complexes have been much studied and ligands with high quantum efficiency have been developed for different lanthanoid ions ...
Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates
(Turun yliopisto, 2021-12-18)
Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ...
Graphene from Graphite by Chemical and Physical Techniques.
(Turun yliopistoAnnales Universitatis Turkuensis A I 500, 2014-12-09)
Graphene is a material with extraordinary properties. Its mechanical and electrical properties are unparalleled but the difficulties in its production are hindering its breakthrough in on applications. Graphene is a ...