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The effects of pharmaceuticals and environmental toxicants on testicular development and function: in vitro and ex vivo study
(Turun yliopisto, 2025-08-15)
Disorders of male reproductive health are becoming increasingly prevalent due to unknown reasons. Pharmaceutical agents and environmental chemicals can cause adverse effects on the reproductive system, but reproductive ...
HSD17BS in steroid and lipid metabolism and lipid disorders: the role of HSD17B12 and HSD17B13
(Turun yliopisto, 2023-10-27)
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of fat within hepatocytes, has become the most common chronic liver disease in developed countries. NAFLD is associated with insulin ...
MicroRNA-mediated regulation of mitosis and taxane sensitivity in breast and ovarian cancer
(Turun yliopisto, 2017-11-24)
Taxanes are microtubule targeting chemotherapeutics that block cell division (mitosis) and induce cell death. Taxanes are commonly used in the neoadjuvant chemotherapy for breast and ovarian cancer. However, the patient ...
Tools and strategies for RNA-sequencing data analysis
(Turun yliopisto, 2023-08-25)
RNA-Sequencing (RNA-seq) has enabled the in-depth study of the transcriptome, becoming the primary research method in the field of molecular biology. The typical aim of RNA-seq is to quantify and detect differentially ...
The role of HSD17B3 in male development and health: Disruption of testosterone production and its effects
(Turun yliopisto, 2024-10-04)
ABSTRACT
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme converting androstenedione (A) to testosterone (T) in human and mouse testes. It is therefore important for male development ...
Development of male reproductive health in puberty and young adulthood
(Turun yliopisto, 2018-11-30)
The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
(Turun yliopisto, 2018-01-19)
At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ...
Novel molecular mechanisms of thyroid disorders: from human diseases to mouse models
(Turun yliopisto, 2023-02-03)
The thyroid gland secretes thyroid hormones (TH), which have a crucial role in metabolism, as well as childhood brain growth and development. The thyroid stimulating hormone (TSH) via its G protein-coupled receptor (TSHR) ...
Function of Germline-specific Ribonucleoprotein granules-from germline to cancer
(Turun yliopisto, 2023-12-15)
Male germ cells undergo complex differentiation from embryonic germ cells, through postnatal spermatogenesis to highly specialized spermatozoa. Precise regulation of gene expression is critical for meiosis and morphological ...
Developmental aspects of male reproductive health: clinical studies on semen quality, cryptorchidism, and puberty
(Turun yliopisto, 2023-08-11)
Current evidence shows increasing rates of male reproductive disorders, including cryptorchidism, hypospadias, poor semen quality, decreased testosterone level, and testicular cancer. Therefore, studies on the physiology ...