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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Schwarz PEH; Zhao JH; Eriksson JG; Kinnunen L; Luan JA; Raitakari OT; Kooner JS; Hassinen M; Ribel-Madsen R; Feitosa MF; Abecasis GR; Mangino M; Kanoni S; Chu AY; Wild SH; Milani L; Pankow JS; Medina-Gomez C; Oostra BA; Boehnke M; Goel A; Beilby J; Wong A; Prokopenko I; Pedersen O; Polasek O; Grewal J; Morris AP; Kajantie E; Perola M; Peters A; Hysi PG; Jokinen E; Spector TD; Mills R; Muller-Nurasyid M; Kutalik Z; Vitart V; Ohlsson C; Walker RW; Bellis C; Hui JN; Viikari JS; Justesen JM; Friedrich N; Albrecht E; Lahti J; Southam L; Tsafantakis E; Lichtner P; Hayward C; Rankinen T; Thorleifsson G; Mohlke KL; Willemsen G; Lakka TA; Hastie N; Husemoen LL; Chasman DI; McArdle WL; Watkins H; Mcknight B; Metspalu A; Palotie A; North KE; Scott RA; Cupples LA; Venturini C; Grarup N; Bragg-Gresham JL; Laitinen T; Teumer A; Ryan KA; Isaacs A; Njolstad I; Rauramaa R; Grassler J; Khaw KT; van der Harst P; Mannisto S; Salvi E; Graff M; Uitterlinden AG; Loos RJF; Bluher M; Hattersley AT; Esko T; Wang SR; Schlessinger D; Huffman JE; Kooner IK; Montasser ME; Willems SM; Bouchard C; van der Most PJ; Kolcic I; Tuomilehto J; Chambers JC; Boomsma DI; Bornstein SR; Pilia MG; Gieger C; Grallert H; Rao DC; Forouhi NG; Hansen T; Lewin AM; Heid IM; Blangero J; Palmer LJ; Fox C; Chines PS; Tonjes A; Hveem K; Penninx BW; Bonnycastle LL; Bruinenberg M; Vohl MC; Wilsgaard T; Stringham HM; Kovacs P; Oldehinkel AJ; Jarvelin MR; Ong KK; Hillege H; Harder MN; Stancakova A; Tachmazidou I; Strauch K; Monda KL; Doring A; Jackson AU; Hamsten A; Bakker SJL; Steinthorsdottir V; van Dongen J; Bergman RN; Bergmann S; Lindgren CM; Eklund N; Shudiner AR; Vartiainen E; Stefansson K; Smit JH; Van Vliet-Ostaptchouk JV; Kuusisto J; Musk AW; Lehtimaki T; Hartman CA; Frayling T; Thorsteinsdottir U; Qi L; Heliovaara M; Hottenga JJ; Salomaa V; Jorgensen T; Wright AF; Tremblay A; Knekt PB; Muller G; Holmen O; Lyssenko V; Kyriakou T; Volker U; Ferreira T; Jalilzadeh S; Jeff JM; Ridker PM; Gansevoort RT; Boerwinkle E; Borecki IB; D'Avila F; Hirschhorn JN; Magi R; Luben R; Sarzynski MA; Barlassina C; Kaplan RC; Cadby G; Ahluwalia TS; Zhang WH; Gjesing AP; Puolijoki H; Cusi D; Smith MT; Koskinen S; Widen E; Manunta P; Zillikens MC; Chiang CWK; Strachan DP; Rice TK; Winkler TW; Hofman A; Kristiansson K; Swertz MA; Koistinen HA; Sparso TH; Farrall M; Havulinna AS; Campbell H; Lindstrom J; Wilson JF; Snieder H; Sorensen TIA; Linneberg A; Uusitupa M; Dimitriou M; O'Connell JR; Eriksson J; Vollenweider P; Jula A; Zeggini E; Deloukas P; Dedoussis G; Farmaki AE; Langenberg C; Scholtens S; van Duijn CM; Mahajan A; Bartz TM; Richards M; Psaty BM; Rivadeneira F; Vandenput L; Justice AE; Cucca F; Hunter DJ; Fischer K; Jousilahti P; Homuth G; Vonk JM; Mihailov E; Perusse L; Sebert S; McCarthy MI; Heard-Costa NL; Leach IM; Nolte IM; Wareham NJ; Yerges-Armstrong LM; Ried JS; Karaleftheri M; Pramstaller PP; Pichler I; Stolk RP; Groop LC; James AL; Swift AJ; Glorioso N; Verweij N; Rose LM; Waeber G; Narisu N; Sung YJ; Rayner NW; Collins FS; Lorbeer R; Hicks AA; Sanna S; Laakso M; Chen YDI; Stirrups K; Osmond C; Paternoster L; Lorentzon M; Ittermann T; Rudan I; Hu F; de Geus EJC; Kahonen M; Gorski M; Stumvoll M; Alves AC; Kuh D; Keinanen-Kiukaanniemi SM

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Horikoshi M; Granell R; Lichtenstein P; Kemp JP; Gilliland F; Custovic A; Henriksen TB; Mook-Kanamori DO; Santa-Marina L; Boomsma DI; Ahluwalia TS; Cavadino A; Strandberg T; Freathy RM; Snieder H; van der Most PJ; Myhre R; Larsson H; Najman JM; Eliasen AU; Almgren P; Beaumont RN; Geller F; Kaprio J; McCarthy MI; Fadista J; Lawlor DA; Frayling TM; Melbye M; St Pourcain B; Hadley D; Hypponen E; Cooper C; Feenstra B; Warrington NM; Panoutsopoulou K; Zemel BS; Liu J; Prasad RB; Cousminer DL; Coin L; Day FR; Lappe JM; Raikkonen K; Pitkanen N; Gauderman WJ; Bond T; Schnurr TM; Korner A; Xu CJ; Magnus P; Lowe WL; Grant SFA; Scott JG; Rivadeneira F; O'Reilly P; Uitterlinden AG; Morris AP; Hayes MG; Holloway JW; Yaghootkar H; Hottenga JJ; Ntalla I; Tyrrell J; Liu XP; Heinrich J; Hattersley AT; Stoltenberg C; Power C; Simpson A; Iniguez C; Kalkwarf HJ; Holt P; Koppelman GH; Middeldorp CM; Wang CA; Ong KK; Lyytikainen LP; Jarvelin MR; Henders AK; Williams GM; Kutalik Z; Standl M; Sorensen TIA; Chen ZH; Paternoster L; Vogelezang S; Yi L; Linneberg A; Sleiman PMM; Bustamante M; Hocher B; Gaillard R; Vuoksimaa E; Lundstrom S; Mahajan A; Timpson NJ; Kumar A; Bradfield JP; Davies GE; Ma RCW; Mace A; Lewin AM; Felix JF; Viikari J; Nolte IM; Watkins WJ; Xu SJ; van Beijsterveldt T; Atalay M; Teo YY; Hakonarson H; Pulkkinen L; Widen EE; Smith GD; Wray NR; Palviainen T; Richmond RC; Mamun AA; Willemsen G; Hartman CA; Melen E; Oberfield SE; Medland SE; Li J; Rose RJ; Ahlqvist E; Eriksson JG; Ang W; Hebebrand J; Das S; McCarthy NS; Kerkhof M; Johansson S; Mannikko M; Duijts L; Bilbao JR; Tiemeier H; Bartels M; Pahkala K; Sebert S; Grarup N; Hirschhorn JN; Sunyer J; Lindi V; Pershagen G; Bonnelykke K; Reynolds RM; Vonk JM; Fedko IO; Borja JB; Charoen P; Eastwood PR; Dedoussis GV; Plomin R; Kulohoma B; Wilson JF; Pennell CE; Kotecha S; Lakka TA; Vrijkotte TGM; Vilor-Tejedor N; Rodriguez A; Adair LS; Oldehinkel AJ; Morgen CS; Salem R; Torrent M; Hinney A; Zeggini E; Tiemeier HN; Groop L; Nohr EA; Kahonen M; Kreiner-Moller E; Selzam S; Strachan DP; Taylor M; Hivert MF; Helgeland O; Karhunen V; Wichmann HE; Robertson NR; Sleiman PMA; Steegers EAP; Lindgren CM; Henderson J; Evans DM; Prokopenko I; Guxens M; Oken E; Murray JC; Gilsanz V; Straker L; Bisgaard H; Auvinen J; Lehtimaki T; Raitakari OT; Mbarek H; Hansen T; Estivill X; Jacobsson B; Curtin JA; Jugessur A; Thiering E; Whitehouse AJO; De Silva NM; Pedersen O; Skotte L; Perry JRB; Magi R; Elliott P; Martin NG; Nivard MG; Mohlke KL; Njolstad PR; Beckmann JS; Monnereau C; Jaddoe VWV; Zafarmand MH; Saw SM; van Duijn CM; Shepherd JA; Lahti J

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as ...

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Lyytikäinen LP; Kähönen M; Havulinna AS; Maan AC; Brody JA; Olesen M; Bis JC; Schramm K; Isaacs A; Rudan I; Yao J; Gögele M; De Grandi A; Ryan K; Shuldiner AR; Gustav Smith J; Kooperberg C; Van Duijvenboden S; Sinagra G; Benjamin EJ; Kerr KF; Felix SB; Cucca F; Lin HJ; Lin H; Campbell H; Thorolfsdottir RB; Stefansson K; Boutin T; Aeschbacher S; Ribeiro ALP; Arnar DO; Polasek O; Taylor KD; Warren HR; Nelson CP; Wilson JF; Lima-Costa MF; Meitinger T; Assa S; Rice K; Souza RP; Mei H; Levy D; Heckbert SR; Harris TB; Smith AV; Morris AP; Montasser ME; Lambiase PD; Lubitz SA; Mishra PP; Ntalla I; Raitakari OT; Benjamin Shoemaker M; Soliman EZ; Seyerle AA; Concas MP; Barnes CLK; Sotoodehnia N; Noordam R; Joshi PK; Haessler J; Kolcic I; Gudnason V; Jula A; Huang PL; Gasparini P; van Duijn CM; London B; Reiner AP; Völker U; Mook-Kanamori DO; Kääb S; Del Greco M F; Thorleifsson G; Lunetta KL; Cutler MJ; Ellinor PT; O'Connell JR; Spector TD; Newton-Cheh CH; van den Berg ME; Uitterlinden A; Weiss S; de Mutsert R; Dominiczak A; Conen D; Salomaa V; Gudbjartsson DF; Wouter Jukema J; Thériault S; Munroe PB; Nikus K; Launer LJ; Sulem P; Strauch K; Rotter JI; Mahajan A; Giedraitis V; Cranley JJ; Riaz MB; Barnes MR; Tarasov KV; Psaty BM; Guo X; Thorsteinsdottir U; Gogarten SM; Stricker BH; Sveinbjornsson G; Fuchsberger C; Arking DE; Correa A; Ramirez J; Caulfield MJ; Choi SH; Smith BH; Boerwinkle E; Peters U; Ingelsson E; Qian Y; Marten J; Risch L; Avery CL; Araujo NM; Weng LC; Sääksjärvi K; Lakatta EG; Porteous DJ; Foco L; Dörr M; Tucker NR; van de Vegte YJ; Macfarlane PW; Kors JA; Ehret GB; Mifsud B; Roden DM; Mangino M; Ford I; Jamshidi Y; Cartwright JH; Lind L; Yldau van der Ende M; Pramstaller PP; Verweij N; Pattaro C; Nadkarni GN; Biggs ML; Lehtimäki T; Murray AD; Laurie CC; Whitsel EA; Tinker A; Hayward C; Alonso A; Cook JP; Samani NJ; Wilson J; Preuss MH; Loos RJF; Roselli C; Holm H; van der Harst P; Hicks AA; Trompet S; Chaffin MD; Orini M; Padmanabhan S; Sundström J; Bottinger EP; Waldenberger M; Jackson RD; Rienstra M; Ulivi S; Müller-Nurasyid M; Stilp A; Fatkin D; Mononen N; Abdullah Said M; Tarazona-Santos E; Peters A; Hall AW; Lindgren CM; Ding J; Hutri-Kähönen N; Sinner MF

<p>The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we ...

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

de Mutsert R; Kritchevsky SB; Heng CK; Vollenweider P; Howard BV; Wong TY; Samani NJ; Tai ES; Dorajoo R; Wu TC; He J; Jonas JB; Scott J; Guo XQ; Li CW; Rose LM; Bowden DW; Gasparini P; Alver M; Kahonen M; Rice K; van Duijn CM; Khor CC; Fau JD; Scott RA; Bartz TM; Sidney S; Fuentes LDL; Warren HR; Ehret G; Smith JA; Penninx BWJH; Wang YJ; Froguel P; Zonderman AB; Lehtimaki T; Hallmans G; Campbell A; Bin Wei W; Province MA; Kooperberg C; Palmas W; Leander K; Kubo M; Stancakova A; Zhu XF; Rankinen T; Boehnke M; Mohlke KL; Elliott P; Watkins H; Raffel LJ; Tham YC; Harris TB; Hagenaars SP; Poiasek O; Nelson CP; Wickremasinghe AR; Vojinovic D; Aschard H; Gieger C; Smith AV; Scott WR; Yu CZ; Winkler TW; O'Connell JR; Koh WP; Cheng CY; Munroe PB; Kutalik Z; Porteous DJ; Marten J; Laurie CC; Heikkinen S; Vitart V; Brumat M; Charumathi S; Ntalla I; Lewis CE; Afaq S; van Dam RM; Gao C; Varga TV; Broeckel U; Magnusson PKE; Feitosa MF; Boerwinkle E; Uitterlinden AG; Deng X; Loh M; Ware EB; Rao DC; Lakka TA; Snieder H; Louie T; Komulainen P; Lin S; Wang LH; Eppinga RN; Perls T; Brown M; Manning AK; Gudnason V; McKenzie CA; Mook-Kanamori DO; Yuan JM; Meitinger T; Hirata M; Yao J; Fisher V; Hartwig FP; Horta BL; Sims M; Burke GL; Momozawa Y; Waldenberger M; Morrison AC; Chambers JC; Li YZ; Eaton CB; Richard MA; Amin N; Freedman BI; Franks PW; Robino A; Langenberg C; Teo YY; Schmidt CO; Takeuchi F; Farrall M; Norris JM; Chakravarti A; Borecki I; Padmanabhan S; Chen X; Sim XL; Ridker PM; Franco OH; Rosendaal FR; Magi R; Liu YM; Launer LJ; van der Harst P; Bielak LF; Rueedi R; Roll K; Zheng W; Wagenknecht LE; Rauramaa R; Harris SE; Felix SB; Weir DR; Sofer T; Caulfield MJ; Kamatani Y; Nolte IM; van der Most PJ; Langefeld CD; Peyser PA; Tan NYQ; Franceschini N; Peters A; Said MA; Nalls MA; Kraja AT; Raitakari OT; Gao H; John U; Gigante B; Christensen K; Divers J; Kuusisto J; Fornage M; Katsuya T; Poulter N; Fox ER; Starr JM; Chen YDI; Milaneschi Y; Evangelou E; Rotter JI; Deary IJ; Luan J; Wen WQ; Liu JJ; Kato N; Kilpelainen TO; Evans MK; Kooner JS; Wojczynski MK; Wang YX; Milani L; Arking DE; Gandin I; Hsu FC; Rotimi CN; Schreiner PJ; Becker DM; Tang H; Tayo BO; Gauderman WJ; Sitlani CM; Schupf N; Weiss S; Gu DF; Laakso M; Stringham HM; Palmer ND; Williams C; Wareham NJ; Kuhnel B; Musani SK; Levy D; Cai QY; Goel A; Sotoodehnia N; Friedlander Y; Ghanbari M; Zhao W; Ding J; Liu JM; Canouil M; Psaty BM; Pereira AC; Lehne B; Brown MR; Shu XO; Riaz M; Connell JM; Chasman DI; Kelly TN; Cupples LA; Taylor KD; de Silva HJ; Chai JF; Duan Q; Krieger JE; Strauch K; Kasturiratne A; Turner ST; Lohman KK; Forouhi NG; He MI; Zhang WH; Horimoto ARVR; Amini M; Ikram MA; Tajuddin SM; Esko T; Gu CC; Jackson AU; Sever PS; Kardia SLR; Noordam R; Pedersen NL; Correa A; Metspalu A; Hagemeijer Y; Matoba N; Boissel M; Forrester T; Hayward C; Shi Y; Bentley AR; Oldehinkel AJ; Sung YJ; Study LC; Schwander K; Laguzzi F; Bouchard C; Aung T; Yanek LR; Zhao JH

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association ...

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

O'Connell J; Li C; Rankinen T; Morrison AC; Wagenknecht LE; Redline S; Marten J; Kühnel B; Psaty BM; Aschard H; Alver M; Zhu X; Rice TK; Lim E; Shu XO; Winkler TW; Wang H; Lakka TA; Evans MK; Manning A; Aslibekyan S; Snieder H; Gieger C; Arnett DK; Sidney SS; Rensen PCN; Nolte IM; Liu J; Amin N; Lehtimäki T; Rice K; Roenneberg T; Peyser P; Marques-Vidal P; Richard M; Boerwinkle E; He M; van der Spek A; Haba-Rubio J; Palmer ND; Peters A; Cupples LA; Loos RJF; Gauderman WJ; Sung YJ; Guo X; Bentley AR; Taylor KD; Milaneschi Y; Bouchard C; Noordam R; Kritchevsky SB; Gao C; Rauramaa R; Bielak L; Kardia S; Kraja A; Adolfo C; Sims M; Munroe PB; Rich SS; Province M; Waldenberger M; Laville V; de Vries PS; Liu Y; Lee J; Gharib SA; Weiss S; Chen H; Schwander K; Strauch K; Kho M; Wu T; Elliott P; van Dijk KW; Homuth G; Lohman KK; Graff ME; Martin LW; Lyytikäinen LP; Schreiner PJ; Becker DM; Kelly TN; Penninx BWJH; Gottlieb DJ; Liu CT; Horimoto AR; Ilkov M; Gudnason V; Raitakari OT; Heinzer R; Zheng W; Kooperberg C; Komulainen P; Yu C; Krieger JE; Evangelou E; Fox EF; Ballantyne C; van Heemst D; van Duijn CM; Xiang YB; Metspalu A; Feitosa M; Mook-Kanamori DO; Hixson JE; Zonderman AB; Wallance RB; Eiriksdottir G; Vojinovic D; Cade BE; Rotimi C; Sofer T; Rotter JI; Franceschini N; Ikram MA; Nalls MA; Bos MM; Grabe HJ; Tajuddin SM; Biermasz NR; Heikkinen S; Swertz MA; Shikany J; Mägi R; Kilpeläinen TO; Wen W; North KE; Reiner AP; Vollenweider P; Fornage M; Wang Z; Völzke H; Luik AI; Dimou N; Bartz TM; Brown MR; Uitterlinden AG; Sitlani CM; Pereira AC; Harris TB; Esko T; Meitinger T; Rao DC; Musani SK; Yanek LR; de Las Fuentes L

<p>Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry ...

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Vestergaard H; Heid IM; Liu CT; Gordon-Larsen P; Vandenput L; den Hoed M; Grallert H; Weir DR; Haller T; Lorentzon M; Blangero J; Ridker PM; Lohman K; Männikkö R; Hansen T; Peters A; Lemarchand L; Sarti C; Olden M; Johnson AD; Huang T; Vohl MC; Mohlke KL; Völker U; Holmens OL; Bandinelli S; Loos RJF; Buyske S; Griffin PJ; Hartman CA; Vollenweider P; Sanna S; Luben R; Qi L; Lehne B; Waeber G; Perola M; De Moor MHM; Lindgren CM; Campbell H; van Grootheest G; Snieder H; Jhun MA; Harris TB; Vitart V; Salomaa V; Wareham NJ; Hofman A; Workalemahu T; Wilson JF; Walker M; Nolte IM; Aadahl M; Bielak LF; Cadby G; Bergmann S; Dueker N; Langenberg C; Hollensted M; Wright AF; Mangino M; Boomsma DI; Justice AE; Monda KL; Rauramaa R; Montgomery GW; Collins FS; Xue LT; Kolcic I; Fornage M; Mahajan A; Pedersen O; Kähönen M; Huppertz C; Glaser S; Klein RJ; Thorand B; Grammer TB; Bouchard C; Corre T; Marques-Vidal PM; Jansson JO; Milaneschi Y; Hindorff L; Amin N; Scott RA; Pasko D; Kooperberg C; Bragg-Gresham JL; Sidney S; Kivimäki M; Ngwa JS; Chu AY; Gieger C; Barroso I; Magl R; Tammelin T; Borja JB; Eriksson J; Dorr M; Smith AV; Kooner JS; Busonero F; Faul JD; Bonnefond A; Luan J; Lakka TA; Kinnunen L; Boerwinkle E; Rose LM; Teumer A; Frayling TM; Juonala M; Abecasis GR; Lim E; Brage S; Demirkan A; North KE; McCarthy MI; Swift AJ; Oldehinkel AJ; Kristiansson K; Hernandez D; Stringham HM; Hottenga JJ; Eicher JD; Adair LS; Sternfeld B; Zhao JH; Bien S; Metspalu A; Ahmad S; Ohlsson C; Qi QB; Zubair N; Quaye L; Koistinen HA; James AL; Wild S; Snitker S; Holzapfel C; Justesen JM; Faerch K; Rankinen T; Scott WR; Whitfield JB; Hutri-Kähönen N; Winkler TW; Tan ST; Fu M; Strauch K; Kleber ME; Gong J; Huth C; Chasman DI; Cornelis M; Martin NG; van Vliet-Ostaptchouk JV; Peters U; Cheng YC; Kilpeläinen TO; Lim U; Tönjes A; Hui J; Kuusisto J; Huffman JE; Graff M; Lehtimaki T; Raitakari OT; Paternoster L; Porteous DJ; Hveem K; Young KL; Ebeling T; Rasmussen-Torvik LJ; Perez J; Hirschhorn JN; Heard-Costa NL; Järvelin MR; Harder MN; Marz W; Männistö S; Chambers JC; Smith JA; Marten J; Jackson AU; Fox CS; Hadley D; Komulainen P; Grarup N; Launer LJ; Chines PS; Linneberg A; Shuldiner AR; Sarzynski MA; Hallmans G; Bertoni AG; Silbernagel G; Cupples LA; Thuillier D; Ahluwalia TS; Strachan DP; Smith BH; Rivadeneira F; Mulas A; Sørensen TIA; Franks PW; Willemsen G; Van der Most PJ; Kvaløy K; Borecki IB; Liu YM; Huang J; Johansson A; Auvinen J; Kutalik Z; Völzke H; O'Connell JR; Savonen K; Penninx BWJH; Hayward C; de Geus EJC; Tuomilehto J; Ong KK; Uitterlinden AG; Peyser PA; Feitosa MF; Smith GD; Hastie ND; Rudan I; Kumari M; Rivera NV; Musk AW; Rawal R; van Duijn CM; Yengo L; Gyllensten U; Gudnason V; Boehnke M; Hocking LJ; Hassinen M; Zillikens MC; Wu Y; Nauck M; Renström F; Kardia SLR; Padmanabhan S; Havulinna AS; Stančáková A; Narisu N; Esko T; Balkau B; Beilby J; Palmer LJ; Eiriksdottir G; Peyrot WJ; Bonnycastle LL; Kuh D; Lyytikäinen LP; Zhao W; Marre M; Wong A; Pérusse L; Haiman CA; Puolijoki H; Nettleton JA; Müller-Nurasyid M; Polasek O; Navarro P; Laakso M; Hayes JE; Prokopenko I; Cucca F; Zhang WH; Bellis C; Barata L; Froguel P; Bergman RN; Tanaka T; Harald K; Delgado GE

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ...

A meta-analysis of genome-wide association studies identifies multiple longevity genes

van Duijn CM; van Der Spek A; Arnold AM; Cummings SR; Duncan R; Seppala I; Zeng Y; Uitterlinden AG; Jylha M; Jagger C; Smith J; Faul JD; Sorensen TIA; Orwoll ES; Perls TT; Rotter JI; Barzilai N; Sarnowski C; Psat BM; Debrabant B; Huisman M; Christensen K; Nohr EA; Robine JM; Blanche H; Tesi N; Liu XM; Province MA; Gudnaso V; Amin N; Ye K; Holstege H; Becker EJ; Slagboom PE; Weir D; Kahonen M; Deelen J; Lieb WG; van Der Flier W; Cordell HJ; Lehtimaki T; Smith AV; Wojczynski MK; Newman AB; Murabito JM; Kardia SLR; Atzmon G; Kirkwood TBL; Ayers KL; Nygaard M; Jansen I; van Der Lee SJ; Karasik D; Galan P; Cubaynes S; Christiansen L; Taylor KD; Deleuze JF; Vaupel JW; Dose J; Martin-Ruiz C; Launer LJ; Biggs ML; Sebastiani P; Franceschi C; Arking DE; Lyytikainen LP; Evans DS; Ware EB; Lunetta KL; Kiel DP; Min JX; Beekman M; van Heemst D; Collerton JC; Nebe A; Zheng WL; Nie C; Davies K; Raitakari OT; Kingston A; Hurme MA; Harris TB; Reinders MJT

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases ...

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Nolte IM; Mychaleckyj JC; Campbell H; Sabo A; Padmanabhan S; Demissie S; Viikari JS; Mbarek H; Kahonen M; Hofman A; Wilson JG; Sijbrands EJ; de Craen AJM; Nikus K; Franco OH; Morrison A; Ripatti S; Joshi PK; Tayo BO; Evangelou E; Jukema JW; de Mutsert R; Gudnason V; Lehne B; Deelen J; van Duijn CM; Kooner JS; White CC; Scott WR; Raitakari OT; Kooner AS; Lehtimaki T; Rivadeneira F; Chambers JC; Forrester T; Trompet S; Boomsma DI; Wilson JF; Gansevoort RT; Smith AV; Verweij N; Huffman JE; Borecki IB; Snieder H; Milaneschi Y; Rice KM; Zhang WH; Vitart V; Campbell A; Hocking LJ; Rudan I; Willemsen G; Elliott P; Salomaa V; Rotter JI; Rich SS; Brody JA; Segura-Lepe MP; van der Harst P; Tan ST; Boerwinkle E; Psaty BM; Cooper RS; Li-Gao RF; Cupples LA; van der Laan SW; Penninx BWJH; de Ruijter HM; Duan Q; Isaacs A; Harris T; Manichaikul A; McKenzie CA; Swertz M; Feitosa MF; van Leeuwen EM; Lyytikainen LP; Pasterkamp G; Oldehinkel AJ; Kolcic I; Marten J; Lange LA; de Geus EJ; Mook-Kanamori DO; van der Most PJ; Zemunik T; Navarro P; Surakka I; Bis JC; van Dijk KW; Uitterlinden AG; Hayward C; Polasek O; van Klinken JB; Dehghan A; Arking DE; Slagboom PE; Ford I

Background So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not ...

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Alonso A; Launer LJ; Klena NT; Psaty BM; Rice KM; de Boer RA; Dorr M; Jamshidi Y; Verweij N; Bork-Jensen J; van Duijn CM; Volzke H; Lambiase PD; Pedersen O; Xie ZJ; Smith BH; Sotoodehnia N; Padmanabhan S; Weiss S; Gudbjartsson DF; Mook-Kanamori DO; Strauch K; Radmanesh F; Stricker BH; Warren HR; Thorsteinsdottir U; Polasek O; Sinagra G; Felix SB; Gulec C; Munroe PB; Ntalla I; Rotter JI; Ulivi S; Isaacs A; Robino A; Bots ML; Apte SS; Lubitz SA; Hall LM; Kahonen M; Li M; Rosand J; Arking DE; Dominiczak AF; Muller-Nurasyid M; Waldenberger M; Schwartz M; Rudan I; Cappellani S; Jukema JW; Spector TD; Iorio A; Trompet S; Stefansson K; Mead TJ; Newton-Cheh CH; Prins BP; Smith AV; Bihlmeyer NA; van der Harst P; Conti FJ; Eijgelsheim M; Sinner MF; Liu XQ; Gudnason V; Mei H; Peters A; Ellinor PT; Kors JA; Perez M; Lyytikainen LP; Lehtimaki T; Kaab S; Vaartjes I; Raitakari OT; Kanters JK; Gabriel GC; Guo XQ; Soliman EZ; Grarup N; Li-Gao RF; Kooperberg C; Lin HJ; Haessler J; Holm H; Nelson CP; Volker U; Tinker A; Lin HH; Uitterlinden A; Harris TB; Arnar DO; Heckbert SR; van den Berg M; van Setten J; Asselbergs FW; Marten J; Hansen T; Gasparini P; Van Duijvenboden S; Ramirez J; Hayward C; Samani NJ; Wilson JG; Sveinbjornsson G; Brody JA; van der Meer P; Linneberg A; Huang PL; Lo CW; Orini M; Liu CT

Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. ...

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Harris TB; Tuomilehto J; Harder MN; James AL; Silbernagel G; Hutri-Kahonen N; Rudan I; Navarro P; Mahajan A; Kolcic I; Kutalik Z; Jackson AU; Balkau B; Marten J; Rankinen T; Stott DJ; Bandinelli S; Liu CT; Schlessinger D; Bien SA; Vestergaard H; Direk N; Holmen OL; van der Laan SW; Alfred T; Scholtens S; Marques-Vidal P; Olden M; Fisher VA; Hocking LJ; Kleber ME; Frayling TM; Eicher JD; Launer LJ; Lim U; Xue L; Lee NR; Lehtimaki T; Metspalu A; Rao DC; Jarvelin MR; Pervjakova N; Rasmussen-Torvik LJ; Chittani M; Strauch K; Lindgren CM; Qi L; Bergmann S; Volzke H; Heid IM; Strachan DP; Hottenga JJ; Hansen T; Haitjema S; Sorensen TIA; Kuh D; Bergman RN; Pasterkamp G; Sennblad B; McCarthy MI; Gong J; Nauck M; Bartz TM; Waeber G; Chasman DI; Strawbridge RJ; Dedoussis G; Justice AE; Wild S; Faul JD; Taylor KD; Chu AY; Hollensted M; Vedantam SL; Raitakari OT; Rauramaa R; Loh M; Eriksson J; Justesen JM; Savonen K; Cupples LA; Borecki IB; Fox CS; Hastie ND; Kivimaki M; Gudnason V; Heath AC; Narisu N; Madden PAF; Mohlke KL; Pisinger C; Wu Y; Eiriksdottir G; Barroso I; Perez J; Musk AW; Heard-Costa NL; Ludolph-Donislawski A; Lind L; Bonnycastle LL; Tyrrell J; Bragg J; Zhao W; Kvaloy K; Hassinen M; Lim E; Rice T; Hadley D; Froguel P; Winkler TW; Padmanabhan S; Gorski M; Chambers JC; Weir DR; Grabe HJ; Hirschhorn JN; Barata L; Curran JE; Campbell H; Peters U; Boehnke M; Peters A; Deng X; Langenberg C; Wilson JF; Loos RJF; de Borst GJ; Zubair N; Marchini J; Tayo BO; Afzal U; Hamsten A; Deloukas P; Hindorff L; Esko T; Chen YDI; Cusi D; Baldassarre D; Palmer LJ; Mellstrom D; Hayward C; de Faire U; Wright AF; Grallert H; Glorioso N; Scott RA; Linneberg A; Kinnunen L; Sarti C; Collins FS; Lorentzon M; Hernandez D; Spector TD; Forrester T; Schurmann C; Hung J; Luben R; Zhang WH; Grammer TB; Smith JA; Middelberg RPS; Smith BH; Oldehinkel AJ; Bielak LF; Johnson AD; Boomsma DI; Jhun MA; Vink JM; Stringham HM; Ingelsson E; Marz W; Zillikens MC; Bakker SJL; North KE; Kramer BK; Gigante B; Jansson JO; Huang J; Kooner JS; Graff M; Bonnefond A; Kardia SLR; Jorgensen ME; Kahonen M; Vonk JM; Polasek O; Ong KK; Corre T; Vollenweider P; Morris AP; Perusse L; Gertow K; Hveem K; Tiemeier H; Franks PW; Slagboom PE; Zimmermann ME; Martin NG; Sanna S; Biffar R; Bottinger E; Ohlsson C; McKnight B; Czajkowski J; Hunter DJ; Stancakova A; Horikoshi M; van der Most PJ; Verweij N; Thuillier D; Komulainen P; Ridker PM; Boerwinkle E; Peyser PA; Waldenberger M; Ferrucci L; Van Vliet-Ostaptchouk JV; Chines PS; Van der Harst P; Staessen JA; Psaty BM; Delgado GE; Rose LM; Afaq S; Eriksson AL; Hartman CA; Boger CA; Beilby J; Grarup N; Adair LS; Young K; Mannikko R; Haiman CA; van Duijn CM; Sarzynski MA; Mueller-Nurasyid M; Ford I; Manichaikul A; Huang T; Rawal R; Amin N; Westendorp RGJ; Nolte IM; Wolffenbuttel BHR; Koistinen HA; Swertz MA; Wu J; Laakso M; Smith AV; Montgomery GW; Fischer K; Willemsen G; Wong A; Le Marchand L; Leander K; Blangero J; Whitfield JB; Ahmad S; Buyske S; Menni C; Cadby G; Gordon-Larsen P; Lupoli S; Vandenput L; Kanoni S; Kumari M; Braga D; Feitosa MF; den Ruijter HM; Jukema W; Sung YJ; Bouchard C; Hallmans G; Thorand B; Abecasis GR; Karlsson M; de Craen AJM; Vitart V; Porteous DJ; Siemelink MA; Qi QB; Lobbens S; Uitterlinden AG; Kolovou G; Tanaka T; McKenzie CA; Lubke G; Kooperberg C; Snieder H; Zhao JH; Ahluwalia TS; Homuth G; Luan J; Cucca F; Renstrom F; Lyytikainen LP; Huffman JE; Teumer A; Swift AJ; Yengo L; Mangino M; Wareham NJ; Sattar N; Lakka TA; Kuusisto J; Buckley BM; Ngwa JS; Trompet S; Kilpelainen TO; Tremoli E; de Geus EJC; Pedersen O; Vohl MC; Juonala M; Cooper RS; Coggeshall S; Bruinenberg M

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...