Aineistot 1-10 / 21
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-15)
Farmakogenetiikka saapui klinikkaan - miten hyödyntää genomitietoa potilastyössä
(Turun yliopisto, 2016-03-02)
Expression and role of decorin in human epithelial cancers - with special reference to bladder, colon and vulva carcinomas
(Turun yliopisto, 2019-05-11)
Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop therapies for skeletal disorders and articular cartilage defects or disorders like osteoarthritis (OA). Specific properties of each ...
The effects of soluble activin type IIB receptor on bone formation and body composition
(Turun yliopisto, 2018-05-04)
Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...
New functions for the cellular oxygen sensor PHD3 in clear cell renal cell carcinoma
(Turun yliopisto, 2018-05-18)
The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...
ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos
Reseptorityrosiinikinaasit (RTK) ovat kasvutekijäreseptoreita, jotka välittävät solujen kasvua, erilaistumista ja selviytymistä. RTK:en yli-ilmentyminen ja mutaatiot ovatkin tavallista erilaisissa sairauksissa, kuten ...
PARP Inhibitors in Prostate Cancer – The Preclinical Rationale and Current Clinical Development
Prostate cancer is the second most commonly diagnosed cancer type in men in the Western world. The majority of prostate cancer patients have a good prognosis, while some prostate cancers advance locally or metastasize. ...
ANO7 in aggressive prostate cancer
(Turun yliopisto, 2020-03-13)
A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...
Focal adhesion mediated regulation of pluripotency : The role of focal adhesions and contractile forces in human pluripotent stem cells
(Turun yliopisto, 2019-11-29)
Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...