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Aineistot 181-190 / 253
Use of preclinical and early clinical data for dose selection of a selective estrogen receptor modulator toremifene in treatment of breast cancer
(Annales Universitatis Turkuensis D 1015Turun yliopisto, 2012-06-15)
In development of human medicines, it is important to predict early and accurately enough
the disease and patient population to be treated as well as the effective and safe dose range
of the studied medicine. This is ...
Regulation of ErbB4 signaling by post-translational modifications
(Annales Universitatis Turkuensis D 1265Turun yliopisto, 2017-02-10)
ErbB4 is a member of the epidermal growth receptor family (EGFR/ErbB1, ErbB2, ErbB3, ErbB4) of receptor tyrosine kinases. ErbB receptors are activated by extracellular growth factor ligands, and control the ...
Biological imaging of challenging targets: Peripheral nerve, mouse bones and cultured osteoclasts
(Turun yliopisto, 2021-05-25)
During this study, advances in bioimaging have affected the biomedical research field. In this thesis, traditional microscopy and selected new techniques, namely microcomputed tomography (µCT), STED microscopy and ...
Diffusion Tensor Imaging as a Diagnostic and Research Tool: A Study on Preterm Infants
(Annales Universitatis Turkuensis D 1096Turun yliopisto, 2014-01-17)
Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique. DTI is based on free thermal motion (diffusion) of water molecules. The properties of diffusion can be represented using parameters ...
Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
(Turun yliopisto, 2017-08-10)
Nitric oxide (NO) is a diatomic gaseous molecule generated in our bodies by enzymes known as NO synthases. More recently another pathway for generation of NO has been delineated in which dietary or endogenous inorganic ...
Luminescence-based assay methods in drug discovery
(Annales Universitatis Turkuensis D 982Turun yliopisto, 2011-10-28)
The drug discovery process is facing new challenges in the evaluation process of the lead compounds as the number of new compounds synthesized is increasing. The potentiality of test compounds is most frequently assayed ...
Oppimateriaalin tuottaminen pään ja kaulan alueen anatomian opetukseen
(Turun yliopisto, 2015-04-23)
Sairauksien ymmärtämisen ja toimenpiteiden tekemisen perustana toimii usein anatomian tarkka tunteminen, joka yhdistyy kliiniseen osaamiseen. Hammaslääkärin työn kannalta erityisesti pään ja kaulan anatomian osaaminen on ...
Receptors and endocytosis of coxsackievirus A9
(Annales Universitatis Turkuensis D 1067Turun yliopisto, 2013-05-25)
Coxsackievirus A9 (CV-A9) belongs to human enteroviruses within family Picornaviridae, which are the main cause of aseptic meningitis. In addition, CV-A9 causes a wide range of other clinical manifestations of acute disease ...
Herpes simplex virus type 1 (HSV-1) pathogenesis and HSV gene therapy of experimental autoimmune encephalomyelitis
(Annales Universitatis Turkuensis D 1074Turun yliopisto, 2013-06-14)
The aim of this thesis was to develop new herpes simplex virus (HSV) vectors for gene therapy of experimental autoimmune encephalomyelitis (EAE), the principal model of multiple sclerosis (MS), and to study the pathogenesis ...
Cell surface interactions of coxsackievirus A9 and human parechovirus 1
(Annales Universitatis Turkuensis D 1283Turun yliopisto, 2017-05-12)
Coxsackievirus A9 (CV-A9) and human parechovirus 1 (HPeV-1) belong to family Picornaviridae, genera Enterovirus and Parechovirus respectively. CV-A9 has been associated with aseptic meningitis, myocarditis in addition to ...