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Structure-based and evolutionary analyses of alternative splicing patterns in carbonic anhydrases
(2019-12-03)
Alternative splicing is a biological process which generates multiple distinct mature mRNAs from a single primary transcript. Several isoforms of alpha carbonic anhydrase exist due to this phenomenon which are categorized ...
The influence of maternal prenatal stress on the infant's gut microbiota development
(2020-08-27)
Early life stress is known to have adverse, long lasting consequences on an infant’s behavioral, emotional and cognitive development, capable of persisting into adulthood. Early life stress initially manifests as maternal ...
Introducing deep learning -based methods into the variant calling analysis pipeline
(2019-05-24)
Biological interpretation of the genetic variation enhances our understanding of normal and pathological phenotypes, and may lead to the development of new therapeutics.
However, it is heavily dependent on the genomic ...
Power analysis for RNA sequencing and mass spectrometry-based proteomics data
(2019-02-12)
RNA-sequencing and mass spectrometry technologies have facilitated the differential expression discoveries in transcriptome and proteome studies. However, the determination of sample size to achieve adequate statistical ...
Development of workflow for picornavirus genome sequence analysis
(2020-07-03)
Picornaviruses are small, non-enveloped, icosahedral, positive stranded RNA viruses and among the most common human pathogens. Some of the clinically important genera for humans are Enterovirus, Hepatovirus, Parechovirus ...
High throughput prediction of inter-protein coevolution
(2018-11-14)
Inter-protein co-evolution analysis can reveal in/direct functional or physical protein interactions. Inter-protein co-evolutionary analysis compares the correlation of evolutionary changes between residues on aligned ...
Normalization of Disease Mentions with Convolutional Neural Networks
(2019-05-22)
Normalization of disease mentions has an important role in biomedical natural language processing (BioNLP) applications, such as the construction of biomedical databases. Various disease mention normalization systems have ...
Identification of dephosphorylated sites in the proximity of recurrent mutations in PP2A targets
(2018-12-12)
Protein Phosphatase 2A (PP2A), a major serine/threonine phosphatase, is known to be involved in the wide range of cellular functions in many cell types. Notably, PP2A’s tumor suppressor function has a great potential for ...
miRNA data analysis workflow
(2019-08-13)
Micro RNAs (miRNA) have been shown to regulate many biological processes by silencing the expression of their target genes. They are small non-coding RNAs that have been found in all types of organisms from eukaryotes to ...
Immunological interactions of virus peptides at the antigen presenting MHC I proteins
(2018-12-13)
Regarding the recent outbreak of Zika virus (ZIKV) infection, there is an urgent need to develop a preventive or a therapeutic ZIKV vaccine. In this thesis, computational analysis was performed to predict suitable peptide ...