Selaus oppiaineen mukaan kokoelmassa VäitöskirjatFysiologia
Aineistot 1-20 / 21
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Androgen receptor therapy resistance in prostate cancer: From the disease model to the mechanisms
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1782 (Turun yliopisto, 08.03.2024)Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in ... -
ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models
Turun yliopiston julkaisuja. Sarja D, Medica - Odontologica : 1364 (Turun yliopisto, 15.06.2018)Abstract: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic prostate cancer is responsive ... -
Clinical studies on testicular growth and descent
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1334 (Turun yliopisto, 02.02.2018)Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ... -
Development of male reproductive health in puberty and young adulthood
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1395 (Turun yliopisto, 30.11.2018)The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ... -
Developmental aspects of male reproductive health: clinical studies on semen quality, cryptorchidism, and puberty
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1729 (Turun yliopisto, 11.08.2023)Current evidence shows increasing rates of male reproductive disorders, including cryptorchidism, hypospadias, poor semen quality, decreased testosterone level, and testicular cancer. Therefore, studies on the physiology ... -
Function of Germline-specific Ribonucleoprotein granules-from germline to cancer
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1762 (Turun yliopisto, 15.12.2023)Male germ cells undergo complex differentiation from embryonic germ cells, through postnatal spermatogenesis to highly specialized spermatozoa. Precise regulation of gene expression is critical for meiosis and morphological ... -
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1332 (Turun yliopisto, 19.01.2018)At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ... -
HSD17BS in steroid and lipid metabolism and lipid disorders: the role of HSD17B12 and HSD17B13
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1747 (Turun yliopisto, 27.10.2023)ABSTRACT Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of fat within hepatocytes, has become the most common chronic liver disease in developed countries. NAFLD is associated with insulin ... -
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1333 (Turun yliopisto, 26.01.2018)Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroidmetabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed ... -
Identification of novel genes involved in the pathophysiology of adrenocortical tumorigenesis
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1318 (Turun yliopisto, 01.12.2017)Adrenocortical tumors (ACT) are relatively common, with a prevalence of 6% in the aging population. They can be divided into benign adenomas (ACA) and malignant carcinomas (ACC). Tumors responding to luteinizing hormone ... -
MicroRNA-mediated regulation of mitosis and taxane sensitivity in breast and ovarian cancer
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1314 (Turun yliopisto, 24.11.2017)Taxanes are microtubule targeting chemotherapeutics that block cell division (mitosis) and induce cell death. Taxanes are commonly used in the neoadjuvant chemotherapy for breast and ovarian cancer. However, the patient ... -
Novel molecular mechanisms of thyroid disorders: from human diseases to mouse models
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1686 (Turun yliopisto, 03.02.2023)The thyroid gland secretes thyroid hormones (TH), which have a crucial role in metabolism, as well as childhood brain growth and development. The thyroid stimulating hormone (TSH) via its G protein-coupled receptor (TSHR) ... -
Old acquaintances and new perspectives into testicular development and function
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1510 (Turun yliopisto, 27.11.2020)Testicular development and function are complex processes that involve synchronization of the proliferation, apoptosis, and differentiation of specific somatic and germ cells to ensure lifelong fertility. Dysregulation of ... -
Outcome of Hsd17b1 gene deletion in ovarian and adipose tissue function : alterations resulting from both HSD17B1 enzyme inhibition and the off-target effect on the Naglu gene
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1329 (Turun yliopisto, 05.01.2018)Steroids comprise a group of hormones that are, in the traditional view, secreted by the adrenal cortex, testes and ovaries, as well as the placenta during pregnancy and that reach their target organs via blood circulation. ... -
Regulation of gonadal steroid synthesis and reproduction : novel roles of hydroxysteroid (17β) dehydrogenase 1
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1324 (Turun yliopisto, 15.12.2017)Estrogens and androgens are critical regulators of several physiological processes,including development and reproduction. In addition, these hormones play key roles in several physiological complications and diseases, ... -
Regulation of human aromatase gene expression in adipose tissue
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1467 (29.02.2020)The conversion of androgens to estrogens is catalyzed by the aromatase enzyme, the product of the CYP19A1 gene, in gonads and peripheral tissues. Estrogens produced in the white adipose tissue (WAT) are postulated to play ... -
Targeting Somatostatin Receptors with Peptide-functionalized Silica Nanoparticles
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1563 (Turun yliopisto, 25.08.2021)ABSTRACT Nano-sized synthetic drug carriers comprise a valuable addition to oncology armaments, opening new avenues for improved delivery of anticancer therapies. Nanocarriers designed to bind surface receptors of tumor ... -
The effect of training background on oxidized lipoprotein lipids and antioxidant capacity in athletes and keep-fit runners
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1379 (Turun yliopisto, 07.12.2018)Background: High-intensity acute exercise is known to induce oxidative stress and may lead to harmful oxidation of lipids, and protein and DNA damage. On the other hand, exercise is known to positively influence risk factors ... -
The Ins and outs of the chromatoid body
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1745 (Turun yliopisto, 13.10.2023)Spermatogenesis is a complex differentiation process that produces millions of genetically unique sperm cells every day. During spermatogenesis the developing germ cells undergo metamorphic changes as they transform from ... -
Tools and strategies for RNA-sequencing data analysis
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1719 (Turun yliopisto, 25.08.2023)RNA-Sequencing (RNA-seq) has enabled the in-depth study of the transcriptome, becoming the primary research method in the field of molecular biology. The typical aim of RNA-seq is to quantify and detect differentially ...
