Viimeksi syötetyt Väitöskirjat
Aineistot 1501-1520 / 3084
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Cellular regulation of the norepinephrine transporter
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1336 (Turun yliopisto, 23.02.2018)The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ... -
Statistical methods for the analysis of high-content organotypic cancer cell culture imaging data
Turun yliopiston julkaisuja. Sarja AI: Astronomica - Chemica - Physica – Mathematica : 574 (Turun yliopisto, 03.03.2018)Organotypic cancer cell cultures combined with modern imaging technology have greatly expanded the possibilities of in vitro cancer research and drug development. In fact, imaging and subsequent image analyses have become ... -
Lateral flow immunoassays with fluorescent reporter technologies
Turun yliopiston julkaisuja. Sarja AI: Astronomica - Chemica - Physica – Mathematica : 575 (Turun yliopisto, 23.02.2018)Lateral flow assays (LFAs) are user-friendly diagnostic test devices most commonly known from the home pregnancy tests. Since their appearance in the market in 1980’s, LFAs have become well-established and products have ... -
Muinaisjäännös ympäristön muutoksessa. Modernin alueidenkäytön vaikutuksia Pirkanmaan muinaisjäännöskantaan
Karhunhammas : 18 (Turun yliopisto, 17.02.2018)Asutushistoriallisesti rikkaassa Pirkanmaan maakunnassa alueidenkäyttö muuttaa ympäristöä usein siellä, missä muinaismuistolailla rauhoitetut kiinteät muinaisjäännökset sijaitsevat. Väitöskirja käsittelee maakunnassa vuosina ... -
Investointipäätöksenteon rationaalisuus kuntakontekstissa – Case-tutkimus suomalaisessa kunnassa
Turun yliopiston julkaisuja. Sarja E: Oeconomica : 24 (Turun yliopisto. Turun kauppakorkeakoulu, 16.02.2018)Investointipäätöksentekoa on tutkittu paljon. Kirjallisuus on pääosin keskittynyt taloudellisen informaation, kuten investointilaskelmien, käyttöön investointien analyysissa. Investointipäätöksenteon taloudellisia ja ... -
Essays on latent factor models in finance
Turun yliopiston julkaisuja. Sarja E: Oeconomica : 23 (Turun yliopisto. Turun kauppakorkeakoulu, 09.02.2018)This dissertation considers the application of latent factor models to financial risk management and asset pricing. The purpose is to provide solutions for modelling and forecasting the dynamics of asset prices, and to ... -
Clinical studies on testicular growth and descent
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1334 (Turun yliopisto, 02.02.2018)Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ... -
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1333 (Turun yliopisto, 26.01.2018)Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroidmetabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed ... -
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1332 (Turun yliopisto, 19.01.2018)At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ... -
On Independent Component Analysis and Supervised Dimension Reduction for Time Series
Turun yliopiston julkaisuja. Sarja AI: Astronomica – Chemica – Physica – Mathematica : 573 (Turun yliopisto, 02.02.2018)The main goal of this thesis work has been to develop tools to recover hidden structures, latent variables, or latent subspaces for multivariate and dependent time series data. The secondary goal has been to write ... -
Insulin resistance, cognition, and brain amyloid accumulation : an epidemiological and a positron emission tomography study
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1331 (Turun yliopisto, 02.02.2018)Insulin resistance is a common phenomenon, closely associated with obesity, and defined as the inability of target tissues to respond normally to insulin. Insulin resistance typically precedes the onset of type 2 diabetes ... -
Factors associated with improved outcomes in intensively treated early rheumatoid arthritis
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1327 (Turun yliopisto, 12.01.2018)The cornerstone of the treatment of early rheumatoid arthritis (RA) is intensive, clinical remission targeted treatment with disease-modifying antirheumatic drugs (DMARDs). The aim of the present study was to elucidate ... -
Physical activity, cardiorespiratory fitness and cardiovascular health : the cardiovascular risk in young Finns study
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1330 (Turun yliopisto, 19.01.2018)Background: High physical activity and cardiorespiratory fitness may protect from the development of cardiometabolic disease outcomes but the mechanisms involved are not fully understood. Aims: The aims of this study ... -
Tannins and other polyphenols in Geranium sylvaticum : Identification, intraplant distribution and biological activity
Turun yliopiston julkaisuja. Sarja AI: Astronomica – Chemica – Physica – Mathematica : 569 (Turun yliopisto, 05.01.2018)This thesis studies the phenolic compounds of Geranium sylvaticum L. It focuses especially on geraniin and related ellagitannins. The literature review covers the phytochemistry of Geranium species, the biological activity ... -
Plan on the move : mobile participation in urban planning state-of-the-art and future potential
Turun yliopiston julkaisuja. Sarja B: Humaniora : 449 (Turun yliopisto, 20.01.2018)Citizen participation in urban planning has been a topic of academic and practical interest since the 1960s. The adoption of information and communication technologies for civic participation, electronic participation, ... -
Developing Exchange-Correlation and Kinetic Energy Functional Approximations for Density Functional Theory
Turun yliopiston julkaisuja. Sarja AI: Astronomica – Chemica – Physica – Mathematica : 572 (Turun yliopisto, 13.01.2018)A nearly endless amount of technology relies on the understanding of the properties of matter and materials. Because the properties emerge from the motion of the electrons within matter, deepest and most accurate understanding ... -
Novel predictors of response and outcome in advanced epithelial ovarian cancer
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1328 (Turun yliopisto, 12.01.2018)Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an alternative treatment approach to primary surgery for primarily inoperable advanced epithelial ovarian cancer (EOC) patients with a poor ... -
Thyroid-stimulating hormone : reference range and relation to cardiovascular risk
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1325 (Turun yliopisto, 05.01.2018)Thyroid dysfunctions, especially subclinical forms, are common and could be related to an elevated cardiovascular risk. Previous data on the associations of thyroid function with cardiovascular disease entities and their ... -
Energy-Efficient and Reliable Computing in Dark Silicon Era
TUCS Dissertations : 228 (Turku Centre for Computer Science, 09.01.2018)Dark silicon denotes the phenomenon that, due to thermal and power constraints, the fraction of transistors that can operate at full frequency is decreasing in each technology generation. Moore’s law and Dennard scaling ... -
Outcome of Hsd17b1 gene deletion in ovarian and adipose tissue function : alterations resulting from both HSD17B1 enzyme inhibition and the off-target effect on the Naglu gene
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1329 (Turun yliopisto, 05.01.2018)Steroids comprise a group of hormones that are, in the traditional view, secreted by the adrenal cortex, testes and ovaries, as well as the placenta during pregnancy and that reach their target organs via blood circulation. ...
