Viimeksi syötetyt Väitöskirjat

Aineistot 761-780 / 2947

    • Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases 

      Merilahti, Johannes
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1558 (Turun yliopisto, 10.09.2021)
      ABSTRACT Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...

    • Targeting Somatostatin Receptors with Peptide-functionalized Silica Nanoparticles 

      Paramonov, Valeriy M.
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1563 (Turun yliopisto, 25.08.2021)
      ABSTRACT Nano-sized synthetic drug carriers comprise a valuable addition to oncology armaments, opening new avenues for improved delivery of anticancer therapies. Nanocarriers designed to bind surface receptors of tumor ...

    • Data analysis tools for mass spectrometry proteomics 

      Suomi, Tomi
      Turun yliopiston julkaisuja. Sarja F, Technica - Informatica : 3 (Turun yliopisto, 17.08.2021)
      ABSTRACT Proteins are large biomolecules which consist of amino acid chains. They differ from one another in their amino acid sequences, which are mainly dictated by the nucleotide sequence of their corresponding genes. ...

    • Queering bioethics: a queer feminist framework for vulnerability and principles 

      Sudenkaarne, Tiia
      Reports from the Department of Philosophy : 47 (Turun yliopisto, 2021)
      Gender and sexual variance invite a cornucopia of philosophically salient inquiries. My dissertation considers them in the realm of bioethics. Bioethics can be defined as a field of philosophy that interrogates ethical, ...

    • Palaeoproterozoic crustal evolution in SW Fennoscandia, Baltic Sea region 

      Salin, Evgenia
      Turun yliopiston julkaisuja. Sarja A II, Biologica - Geographica – Geologica : 382 (Turun yliopisto, 20.08.2021)
      ABSTRACT The Palaeoproterozoic crustal evolution of the Fennoscandian Shield involves significant crustal growth with a marked zonation from older rocks in the northeast to younger rocks in the southwest. Following the ...

    • Bullying among students with reading difficulties 

      Turunen, Tiina
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser B: Humaniora : 544 (Turun yliopisto, 13.08.2021)
      Reading difficulties (RDs) constitute the most prevalent type of learning disabilities. They are easily noticed by classmates, may cause frustration, and are often accompanied by emotional, behavioral, and interpersonal ...

    • Biosynthesis and evolution of anthracyclines 

      Nji Wandi, Benjamin
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 649 (Turun yliopisto, 20.08.2021)
      Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...

    • Novel imaging and image-guided therapy of prostate cancer 

      Anttinen, Mikael H.J.
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1555 (Turun yliopisto, 27.08.2021)
      Whole-gland prostate surgery and radiotherapy, the established approaches to localised prostate cancer (PCa), usually cause substantial adverse effects. Targeted image-guided cancer therapy has gained acceptance through ...

    • Body size, body composition and glucose tolerance with special reference to adult height, body surface area, fat and lean body mass 

      Rehunen, Simo
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1539 (Turun yliopisto, 03.09.2021)
      Body size and body composition have long interested mankind and their assessments are considered key factors for the evaluation of overall health status. Although the role of obesity – mostly applying body mass index (BMI) ...

    • Digital transformation in an incumbent organisation: the co-enactment of digital transformation through macro- and micro-level activities 

      Zimmer, Markus Philipp
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 76 (Turun yliopisto. Turun kauppakorkeakoulu, 20.08.2021)
      Digital transformation forms an important organisational response to digital technologies and their potential digital disruptions. Especially incumbent organisations face the risk of a diminished market position if they ...

    • Äidin rajat – Mediateknologinen toimijuus työelämän tietokoneistumisesta sosiaalisen median aikakaudelle 

      Kaarakainen, Suvi-Sadetta
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. B: Humaniora : 545 (Turun yliopisto, 03.09.2021)
      Kulttuurihistorian alaan kuuluvassa väitöstutkimuksessa tutkitaan äitien mediateknologisen toimijuuden muotoutumista Suomessa 1980-luvulta 2010- luvulle työelämän, (perhe)arjen ja kulttuuristen määritysten konteksteissa. ...

    • Essays in health economics 

      Nurminen, Mikko
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser E: Oeconomica : 77 (Turun yliopisto. Turun kauppakorkeakoulu, 20.08.2021)
      This doctoral thesis studies efficiency in health care provision, with a dual focus on two themes. The first theme studies empirically how the introduction of health information technology affects access to prescription ...

    • Lyme borreliosis: diagnostics, treatment and the role of healthcare services 

      Kortela, Elisa
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1562 (Turun yliopisto, 20.08.2021)
      Lyme borreliosis (LB) is the most common tick-borne disease in Europe, caused by spirochete Borrelia burgdorferi sensu lato. Approximately 3–16% of patients with B. burgdorferi infection develop neurological symptoms, ...

    • Expectation incongruence in music and code reading: The eye-tracking approach 

      Chitalkina, Natalia
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser B: Humaniora : 543 (Turun yliopisto, 20.08.2021)
      Humans create and use different kinds of languages in order to store, view, and convey various types of information. Natural languages, such as English, allow people to communicate with each other in everyday and professional ...

    • Metabolic effects of the gastrointestinal hormone secretin with focus on brown adipose tissue 

      Laurila, Sanna
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1560 (Turun yliopisto, 13.08.2021)
      In recent years, brown adipose tissue (BAT) has been of interest in metabolic research, because its activity is associated with reduced cardiovascular risk, insulin resistance and obesity. Since cardiovascular disease ...

    • In search of new facts: interwar Japanese military intelligence activities in the Baltic states and Finland: 1918–1940 

      Masunaga, Shingo
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. B: Humaniora : 541 (Turun yliopisto, 06.08.2021)
      This thesis is the world’s first ever academic work clarifying the interwar Japanese military intelligence activities in the Baltic Sea region. These activities can be divided into three periods: 1) Planning and Research ...

    • Empirical modelling of solar energetic particles 

      Raukunen, Osku
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 648 (Turun yliopisto, 28.06.2021)
      Solar energetic particles (SEPs) are an important component of space weather. They pose a serious radiation hazard to electronic equipment and biological organisms in space. They are produced in explosive events such as ...

    • Varhaiskasvatus eri kieli- ja kulttuuritaustaisten lasten osallisuuden ja oppimisen mahdollistajana 

      Arvola, Outi
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. B: Humaniora : 539 (Turun yliopisto, 23.06.2021)
      Tämä väitöskirjatutkimus paikantuu kasvatustieteen, yhteiskuntatieteen ja osin maahanmuuttotutkimuksen tutkimuskontekstiin. Tutkimuksen tavoitteena oli selvittää, miten suomalainen varhaiskasvatus tukee eri kieli- ja ...

    • Evolution of the Svecofennian Bedrock in Southern Finland - Spatial and temporal changes in the mantle-derived magmatism and mantle-crust interaction 

      Kara, Jaakko
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A II: Biologica - Geologica : 381 (Turun yliopisto, 23.06.2021)
      The Svecofennian orogen in the central Fennoscandian Shield was formed between 1.96–1.77 Ga. This study focuses on characterizing the temporal and spatial changes of the mantle derived and related magmas in southern Finland ...

    • Measurement simulability and incompatibility in quantum theory and other operational theories 

      Leppäjärvi, Leevi
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Mathematica : 646 (Turun yliopisto, 17.06.2021)
      Quantum theory is a particularly important instance of an operational theory.By looking at quantum theory from the perspective of more abstract operational framework one is able to study its properties in a wider context. ...