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Aineistot 181-190 / 224
Tissue Proteomes: Quantitative Mass Spectrometry of Murine Liver and Ovarian Endometrioma
(Annales Universitatis Turkuensis D 1236Turun yliopisto, 2016-09-02)
A human genome contains more than 20 000 protein-encoding genes. A human proteome, instead, has been estimated to be much more complex and dynamic. The most powerful tool to study proteins today is mass ...
Integrins in Tumorigenesis and Cancer Cell Invasion
(Annales Universitatis Turkuensis D 1054Turun yliopisto, 2013-02-08)
The integrin family of transmembrane receptors are important for cell-matrix adhesion
and signal transmission to the interior of the cell. Integrins are essential for many
physiological processes and defective integrin ...
Identification and characterisation of a novel adhesin of Streptococcus suis and its use as a target of adhesion inhibition and bacterial detection
(Annales Universitatis Turkuensis D 1042Turun yliopisto, 2012-11-16)
Streptococcus suis is an important pig pathogen but it is also zoonotic, i.e. capable of causing
diseases in humans. Human S. suis infections are quite uncommon but potentially life-threatening
and the pathogen is an ...
The Roots of Neurofibromas in Neurofibromatosis 1 — A Question of Multipotency, Differentiation and Hiding
(Annales Universitatis Turkuensis D 1034Turun yliopisto, 2012-10-12)
Neurofibromatosis type 1 (NF1) is an autosomal dominant cancer predisposition
syndrome that affects about 1 in 3500 individuals worldwide. NF1 is caused by
mutations in the NF1 gene that encodes the tumor suppressor ...
Wnt signaling in the regulation of bone and cartilage metabolism
(Turun yliopisto, 2021-10-22)
Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...
Fadolmidine – an alpha2-adrenoceptor agonist for spinal analgesia : analgesic effect and safety in preclinical in vivo models
(Turun yliopisto, 2021-01-29)
Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ...
Novel PP2A biomarkers in cancer
(Turun yliopisto, 2021-04-09)
Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited ...
Genetics of inherited dementing disorders – Special emphasis on Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease and primary familial brain calcification
(Annales Universitatis Turkuensis D 1266Turun yliopisto, 2017-01-21)
Advances in genotyping and sequencing technologies have enabled the identification of common and rare genetic variation associated with dementia. This thesis aimed to examine the genetic background of ...
New perspectives on the melanocortins and their cardiovascular effects: Potential implications for the treatment of cardiovascular diseases with melanocortin analogues
(Annales Universitatis Turkuensis D 1050Turun yliopisto, 2013-01-11)
The melanocortin peptides, including melanocyte-stimulating hormones, α-, β- and
γ-MSH, are derived from the precursor peptide proopiomelanocortin and mediate their
biological actions via five different melanocortin ...
Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...