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Aineistot 41-50 / 224
Intestinal permeability in pregnancy : dietary and microbial determinants and metabolic consequences
(Turun yliopisto, 2017-11-10)
Metabolic disorders during pregnancy may challenge the mother and child to longterm health complications. Emerging data indicates a link between increased intestinal permeability and metabolic risk markers in a non-pregnant ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop
therapies for skeletal disorders and articular cartilage defects or disorders like
osteoarthritis (OA). Specific properties of each ...
Clinical studies on testicular growth and descent
(Turun yliopisto, 2018-02-02)
Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...
Innate immune system as the driver of Rheumatoid Arthritis
(Turun yliopisto, 2017-12-02)
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease traditionally believed to be driven primarily by the adaptive immune cells. However, a large infiltrate of innate cells can be seen in the inflamed ...
Regulation of B cell development by transcription factors IRF4 and BACH2
(Turun yliopisto, 2017-10-20)
B lymphocytes—major cell types mediating an adaptive immunity—recognize a vast variety of structures by B cell antigen receptors (BCR). Activated B cells can form germinal centers, undergo antigen-induced affinity maturation ...
Identification of novel genes involved in the pathophysiology of adrenocortical tumorigenesis
(Turun yliopisto, 2017-12-01)
Adrenocortical tumors (ACT) are relatively common, with a prevalence of 6% in the aging population. They can be divided into benign adenomas (ACA) and malignant carcinomas (ACC). Tumors responding to luteinizing hormone ...
HSD17B12 – an enzyme with a role in embryonic development, normal ovarian function and cancer
(Turun yliopisto, 2018-01-19)
At present, 14 different types of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) enzymes have been characterized. These enzymes differ from each other according to tissue distribution, substrate specificity, subcellular ...
Biomarkers in stage II colorectal cancer
(Turun yliopisto, 2020-02-21)
The risk of recurrence of stage II colorectal cancer is difficult to predict. A part of recurrences take place among patients without any of the known high-risk factors such as lymphovascular invasion or preoperative ...
Genetics of inherited small vessel diseases – in search of a novel small vessel disease and modifiers of the clinical course of CADASIL
(Annales Universitatis Turkuensis D 1198Turun yliopisto, 2015-11-21)
The genetic and environmental risk factors of vascular cognitive impairment are still largely unknown. This thesis aimed to assess the genetic background of two clinically similar familial small vessel ...
Multi-omics analysis of early molecular mechanisms of type 1 diabetes
(Turun yliopisto, 2021-12-17)
Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ...