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The Structural Basis for inorganic Pyrophosphatase Catalysis and Regulation
(Turun yliopistoAnnales Universitatis Turkuensis A I 417, 2011-06-01)
Inorganic pyrophosphatases (PPases) are essential enzymes for every living cell. PPases provide the necessary thermodynamic pull for many biosynthetic reactions by hydrolyzing pyrophosphate. There are two types of PPases: ...
Lanthanide Chelates as Donors in Fluorescence Resonance Energy Transfer: Exciting Prospects for Bioaffinity Assay Detection
(Turun yliopistoAnnales Universitatis Turkuensis A I 398, 2009-06-26)
Fluorescence resonance energy transfer (FRET) is a non-radiative energy transfer from a fluorescent donor molecule to an appropriate acceptor molecule and a commonly used technique to develop homogeneous assays. If the ...
Molecular Mechanisms and Interactions in Regulation of Photosynthetic Reactions
(Turun yliopistoAnnales Universitatis Turkuensis A I 493, 2014-10-24)
In photosynthesis, light energy is converted to chemical energy, which is consumed for carbon assimilation in the Calvin-Benson-Bassham (CBB) cycle. Intensive research has significantly advanced the understanding of how ...
Highly functional binding surface for miniaturised solid-phase immunoassays. - A spot story -
(Turun yliopistoAnnales Universitatis Turkuensis A I 391, 2009-03-06)
Several bioaffinity assays are based on the detection of an analyte which is bound on a solid substrate via biochemical interaction. These so called solid phase assays are based on the adhesion of the primary binding partner ...
Characterisation of Human Neutral and Lysosomal alpha-Mannosidases
(Turun yliopistoAnnales Universitatis Turkuensis A I 433, 2011-12-16)
Neutral alpha-mannosidase and lysosomal MAN2B1 alpha-mannosidase belong to glycoside hydrolase family 38, which contains essential enzymes required for the modification and catabolism of asparagine-linked glycans on proteins. ...
Glutathione Transferases as Detoxification Agents: Structural and Functional Studies
(Annales Universitatis Turkuensis D 1240Turun yliopisto, 2016-08-26)
Glutathione transferases (GSTs) are a diverse family of enzymes that catalyze the glutathione-dependent detoxification of toxic compounds. GSTs are responsible for the conjugation of the tripeptide ...
Early Life Intestinal Microbiota in Health and in Atopic Eczema
(Turun yliopisto, 2015-05-05)
Decrease in microbial contacts in affluent societies is considered to lie behind the rise in allergic and other chronic inflammatory diseases during the last decades. Indeed, deviations in the intestinal microbiota composition ...
Sensory and Non-sensory Factors Behind the Liking and Choice of Healthy Food Products
(Turun yliopisto, 2010-01-15)
A healthy and balanced diet can reduce health problems, such as overweight and metabolic syndrome. In general, people have a considerably good knowledge of what constitutes a healthy diet and how they could achieve it with ...
The Structure and Function of αI Domains in Collagen Receptor and Leukocyte Integrins
(Turun yliopistoAnnales Universitatis Turkuensis A I 453, 2012-12-21)
Integrins are heterodimeric, signaling transmembrane adhesion receptors that connect the intracellular actin microfilaments to the extracellular matrix composed of collagens and other matrix molecules. Bidirectional signaling ...
Structural and functional Studies of angucycline tailoring enzymes
(Turun yliopistoAnnales Universitatis Turkuensis A I 517, 2015-06-26)
Polyketides are a diverse group of natural products produced in many bacteria, fungi and plants. These metabolites have diverse biological activities and several members of this group are in clinical use as ...