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Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...
Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells
(Annales Universitatis Turkuensis D 1084Turun yliopisto, 2013-09-13)
Human embryonic stem cells are pluripotent cells capable of renewing themselves and differentiating to specialized cell types. Because of their unique regenerative potential, pluripotent cells offer new opportunities for ...
Transcriptional Profiling of Organ‐Specific Autoimmunity in Human
(Annales Universitatis Turkuensis D 983Turun yliopisto, 2011-11-04)
Our understanding of the pathogenesis of organ‐specific autoinflammation has been restricted by limited access to the target organs. Peripheral blood, however, as a preferred transportation route for immune cells, provides ...
Detection, Identification and Molecular Variation of Human Enteroviruses
(Annales Universitatis Turkuensis D 1201Turun yliopisto, 2015-11-28)
Picornaviruses are the most common human viruses and the identification of the picornaviruses is nowadays based on molecular techniques, for example, reverse transcriptase polymerase ...
The role of extracellular matrix macromolecules in cancer and diabetic macroangiopathy – with special reference to decorin and hyaluronan
(Annales Universitatis Turkuensis D 1218Turun yliopisto, 2016-03-05)
The central role of extracellular matrix (ECM) macromolecules in diseases such as cancer and atherosclerotic vascular diseases including diabetic macroangiopathy is indisputable. Decorin and hyaluronan ...
Development of male reproductive health in puberty and young adulthood
(Turun yliopisto, 2018-11-30)
The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
The Chromatoid body entourage: Molecular characterization of the Chromatoid body‐associated cytoplasmic vesicles
(Turun yliopisto, 2015-11-27)
Spermatogenesis is a unique process compared to cell differentiation in somatic tissues. Germ cells undergo a considerable number of metabolic and morphological changes during their differentiation: they initially ...
PV-1: Leukocyte trafficking molecule and vascular marker
(Annales Universitatis Turkuensis D 1072Turun yliopisto, 2013-06-07)
The distinction between lymphatic vessels and blood vessels is a crucial factor in
many studies in immunology, vascular biology and cancer biology. They both share
several characteristics and perform related, though ...
Generation and Characterization of Knockout Mice and Analysis of Patient Material Demonstrates a Role for Tissue Inhibitor of Metalloproteinases 4 (Timp4) in the Cardiovascular System and Tumor Metastasis
(Annales Universitatis Turkuensis D 1027Turun yliopisto, 2012-08-31)
This thesis focuses on tissue inhibitor of metalloproteinases 4 (TIMP4) which is the
newest member of a small gene and protein family of four closely related endogenous
inhibitors of extracellular matrix (ECM) degrading ...
System-level characterization of Th2 cell development and immune cell responses to ZnO and TiO2 nanoparticles
(Annales Universitatis Turkuensis D 1064Turun yliopisto, 2013-04-26)
Asthma and allergy are common diseases and their prevalence is increasing. One of the hypotheses that explains this trend is exposure to inhalable chemicals such as traffi c-related air pollution. Epidemiological research ...