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New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults
apoE, a key regulator of plasma lipids, mediates altered functionalities in lipoprotein metabolism and thus affects the risk of coronary artery disease (CAD). The significance of different apoE polymorphisms remains unclear; ... -
Market Shaping towards Sustainability – A Case Study in the Market for Guarantees of Origin for Renewable Electricity
IMP Conference Papers<p>According to the Market Studies literature, markets are not stable structures but evolving plastic entities, open to market shaping attempts by the actors who generate their form. Market shaping occurs through interdependent ... -
Huumeiden käyttäjien vakavat MRSA-infektiot ovat lisääntyneet
<p>Lähtökohdat Viime vuosina Husin alueella, Varsinais-Suomessa ja Pirkanmaalla on todettu aiempaa enemmän metisilliinille resistentin Staphylococcus aureuksen (MRSA) aiheuttamia veriviljelypositiivisia infektioita huumeita ... -
Feasibility of FreeSurfer Processing for T1-Weighted Brain Images of 5-Year-Olds: Semiautomated Protocol of FinnBrain Neuroimaging Lab
<p>Pediatric neuroimaging is a quickly developing field that still faces important methodological challenges. Pediatric images usually have more motion artifact than adult images. The artifact can cause visible errors in ... -
Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature
Fibrosis is one of the key healing responses to injury, especially within the heart where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated ... -
68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice
Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated ... -
Comparison of Word and Character Level Information for Medical Term Identification Using Convolutional Neural Networks and Transformers
Studies in Health Technology and InformaticsComplexity and domain-specificity make medical text hard to understand for patients and their next of kin. To simplify such text, this paper explored how word and character level information can be leveraged to identify ... -
HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma
<p><strong>Objectives: </strong>We evaluated usability of single base substitution signature 3 (Sig3) as a biomarker for homologous recombination deficiency (HRD) in tubo-ovarian high-grade serous carcinoma (HGSC).</p><p ... -
Associations of active commuting and leisure-time physical activity with perceived cognitive function and work ability among Finnish employed adults: a population-based study
BackgroundRegular active commuting - that is, walking or cycling to work - can improve cardiometabolic health and physical fitness among employed adults. This study aimed to examine whether regular active commuting is also ... -
Measure of shape for object data
Object data analysis is concerned with statistical methodology for datasets whose elements reside in an arbitrary, unspecified metric space. In this work we propose the object shape, a novel measure of shape/symmetry for ... -
Brain Responses to Peer Feedback in Social Media Are Modulated by Valence in Late Adolescence
Previous studies have examined the neural correlates of receiving negative feedback from peers during virtual social interaction in young people. However, there is a lack of studies applying platforms adolescents use in ... -
Template-free Data-to-Text Generation of Finnish Sports News
NEALT Proceedings Series<p>News articles such as sports game reports are often thought to closely follow the underlying game statistics, but in practice they contain a notable amount of background knowledge, interpretation, insight into the ... -
Fosfataasien avulla syövän kimppuun
Syöpäsolujen sisäisten viestiverkostojen toiminnan muuttuminen on tärkeä syövän syntymekanismi ja vaikuttaa monien syöpälääkkeiden vasteisiin. Tärkein viestiverkostojen toimintaa säätelevä biokemiallinen mekanismi on ... -
Euclid preparation LXVIII: Extracting physical parameters from galaxies with machine learning
The Euclid mission is generating a vast amount of imaging data in four broadband filters at a high angular resolution. This data will allow for the detailed study of mass, metallicity, and stellar populations across galaxies ... -
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking
<p><strong>Aims: </strong>Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and function, and cardiac ... -
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors
<p>Larynx squamous cell carcinoma (LSCC) is characterized by complex genotypes, with numerous abnormalities in various genes. Despite the progress in diagnosis and treatment of this disease, 5-year survival rates remain ... -
Enhancing Mindfulness, Emotional Well-being and Strengths in Parenting via an Eight-week Flourishing Families Intervention
<p> Being a parent influences both parent’s and children’s well-being in many ways; therefore, developing interventions that support parents in their important role as a parent is vital. The current study evaluated the ...